T-907

Temazepam solution

1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant^®

• Synonym(s): Temazepam Standard Solution
• Empirical Formula (Hill Notation): C₁₆H₁₃ClN₂O₂
• Molecular Weight: 300.74
• EC Number: 200-659-6
• MDL number: MFCD00057904
• UNSPSC Code: 41116107
• PubChem Substance ID: 329826895
• NACRES: NA.24

Properties

• grade: certified reference material
• form: liquid
• feature: Snap-N-Spike^®/Snap-N-Shoot^®
• packaging: ampule of 1 mL
• manufacturer/tradename: Cerilliant^®
• drug control: Narcotic Licence Schedule B (Switzerland); psicótropo (Spain); Decreto Lei 15/93: Tabela IV (Portugal)
• concentration: 1.0 mg/mL in methanol
• technique(s): gas chromatography (GC): suitable; liquid chromatography (LC): suitable
• application(s): clinical testing
• format: single component solution
• shipped in: wet ice
• storage temp.: −20°C
• SMILES string: CN1C(=O)C(O)N=C(c2ccccc2)c3cc(Cl)ccc13
• InChI: 1S/C16H13ClN2O2/c1-19-13-8-7-11(17)9-12(13)14(18-15(20)16(19)21)10-5-3-2-4-6-10/h2-9,15,20H,1H3
• InChI key: SEQDDYPDSLOBDC-UHFFFAOYSA-N
• Gene Information: human ... GABRA1(2554) , GABRA2(2555) , GABRA3(2556) , GABRA4(2557) , GABRA5(2558) , GABRA6(2559) , GABRB1(2560) , GABRB2(2561) , GABRB3(2562) , GABRD(2563) , GABRE(2564) , GABRG1(2565) , GABRG2(2566) , GABRG3(2567) , GABRP(2568) , GABRQ(55879)

Description

General description

Sold under the trade names Restoril^® and Normison, temazepam is a benzodiazepine approved for the short term treatment of insomnia. The drug has anti-anxiety, anticonvulsant and skeletal muscle relaxant properties. This certified Snap-N-Spike^® solution is suitable for a variety of GC/MS and LC/MS testing applications from forensic analysis and pain prescription monitoring to clinical toxicology and urine drug testing.

Application

• Evaluation of an activated carbon disposal system: This study evaluates an activated carbon disposal system for safely disposing of model prescription sedative medications, including Temazepam, focusing on the environmental aspects and the prevention of medication abuse (Dasht Bozorg et al., 2020).


• Rapid determination of benzodiazepines in pharmaceuticals: Research on the rapid determination of benzodiazepines, including Temazepam, using surface-enhanced Raman scattering demonstrates potential applications in the identification of counterfeit pharmaceuticals (Kimani et al., 2021).


• Biologically active benzodiazepine metabolites: A study on the formation of biologically active benzodiazepine metabolites in hydroponic conditions used Arabidopsis thaliana cell cultures to explore environmental and pharmacological impacts, relevant to Temazepam research (Dudley et al., 2019).


• Racemization of chiral 1,4-benzodiazepines: Investigation into the racemization of oxazepam and other 1,4-benzodiazepines in aqueous solution provides insights into the stability and behavior of these compounds, which includes Temazepam, under laboratory conditions (Hok et al., 2019).

Legal Information

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany

Restoril is a registered trademark of Mallinckrodt Inc.

Snap-N-Shoot is a registered trademark of Cerilliant Corporation

Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Pictograms: GHS02,GHS06,GHS08
• Signal Word: Danger
• Hazard Statements: H225,H301 + H311 + H331,H370
• Precautionary Statements: P210 - P233 - P280 - P301 + P310 - P303 + P361 + P353 - P304 + P340 + P311
• Hazard Classifications: Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
• Target Organs: Eyes,Central nervous system
• Storage Class Code: 3 - Flammable liquids
• WGK: WGK 2
• Flash Point(F): 49.5 °F - closed cup
• Flash Point(C): 9.7 °C - closed cup