O4139

Orlistat

≥98% (HPLC), solid, lipase inhibitor

• Synonym(s): (−)-Tetrahydrolipstatin, N-Formyl-L-leucine (1S)-1-[[(2S,3S)-3-hexyl-4-oxo-2-oxetanyl]methyl]dodecyl ester, Ro-18-0647
• Empirical Formula (Hill Notation): C₂₉H₅₃NO₅
• CAS Number: 96829-58-2
• Molecular Weight: 495.73
• MDL number: MFCD05662360
• UNSPSC Code: 41106300
• PubChem Substance ID: 24724564
• NACRES: NA.77

Properties

• product name: Orlistat, ≥98%, solid
• biological source: synthetic (organic)
• Assay: ≥98%
• form: solid
• color: white
• mp: <50 °C
• solubility: DMSO: 19 mg/mL
• originator: Roche
• storage temp.: 2-8°C
• SMILES string: CCCCCCCCCCC[C@@H](C[C@@H]1OC(=O)[C@H]1CCCCCC)OC(=O)[C@H](CC(C)C)NC=O
• InChI: 1S/C29H53NO5/c1-5-7-9-11-12-13-14-15-16-18-24(34-29(33)26(30-22-31)20-23(3)4)21-27-25(28(32)35-27)19-17-10-8-6-2/h22-27H,5-21H2,1-4H3,(H,30,31)/t24-,25-,26-,27-/m0/s1
• InChI key: AHLBNYSZXLDEJQ-FWEHEUNISA-N
• Gene Information: human ... LIPF(8513) , PNLIP(5406)

Description

General description

Orlistat acts as a gastric lipase inhibitor that reduces fat absorption.

Application

Orlistat has been used as an inhibitor:

• of fatty acid synthase in long-term estrogen-deprived (LTED) variant cell lines
• of lipase in screening lipase inhibition by raspberry extract
• in in vitro pancreatic lipase activity assay

Biochem/physiol Actions

Orlistat impairs intestinal fat absorption and is effective in weight management. It is regarded as a safe drug for treating obesity. It delays the progression of type 2 diabetes mellitus especially in obese and improves glycemic parameters. Long term usage of orlistat results in improved weight reduction and it may not contribute in colorectal carcinogenesis.

Orlistat, used in obesity research, is a pancreatic lipase inhibitor that acts locally in the gastrointestinal tract to inhibit lipase.

Features and Benefits

This compound was developed by Roche. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Other Notes

Solution is not completely clear, small particles may remain floating.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves