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21980

Sigma-Aldrich

Cardiogreen

for microscopy

Synonym(s):

Foxgreen, IC Green, Indocyanine green

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About This Item

Empirical Formula (Hill Notation):
C43H47N2NaO6S2
CAS Number:
Molecular Weight:
774.96
Beilstein:
4115884
EC Number:
MDL number:
UNSPSC Code:
12171500
PubChem Substance ID:
NACRES:
MA.02

grade

for microscopy

Quality Level

form

powder

color

green to very dark green

solubility

water: 0.01 g/10 mL

ε (extinction coefficient)

≥115 at 386-396 nm in water
≥2000 at 774-784 nm in water
≥900 at 712-722 nm in water

application(s)

diagnostic assay manufacturing
hematology
histology

storage temp.

room temp

SMILES string

[Na+].CC1(C)/C(=C\C=C\C=C\C=C\C2=[N+](CCCCS([O-])(=O)=O)c3ccc4ccccc4c3C2(C)C)N(CCCCS([O-])(=O)=O)c5ccc6ccccc6c15

InChI

1S/C43H48N2O6S2.Na/c1-42(2)38(44(28-14-16-30-52(46,47)48)36-26-24-32-18-10-12-20-34(32)40(36)42)22-8-6-5-7-9-23-39-43(3,4)41-35-21-13-11-19-33(35)25-27-37(41)45(39)29-15-17-31-53(49,50)51;/h5-13,18-27H,14-17,28-31H2,1-4H3,(H-,46,47,48,49,50,51);/q;+1/p-1

InChI key

MOFVSTNWEDAEEK-UHFFFAOYSA-M

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General description

Cardiogreen is a dye used for microscopy. This dye has its maximum extinction at the same wavelength as reduced and oxygenated haemoglobin meet making it possible to record the oxygen saturation in blood. This dye has no side-effects.

Application

Cardiogreen was injected in animals intravenously for dynamic optical imaging system to study the capability of capturing the in vivo biodistribution kinetics.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Other Notes

A diagnostic aid in the determination of hepatic function

Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Elizabeth M C Hillman et al.
Nature photonics, 1(9), 526-530 (2008-11-01)
Optical molecular imaging in small animals harnesses the power of highly specific and biocompatible contrast agents for drug development and disease research1-7. However, the widespread adoption of in vivo optical imaging has been inhibited by its inability to clearly resolve
C.M. Leevy et al.
Probl. Liver Dis. (Review), 42-42 (1979)
B E Schaafsma et al.
BJOG : an international journal of obstetrics and gynaecology, 120(6), 758-764 (2013-02-20)
This study aims to confirm the feasibility of near-infrared (NIR) fluorescence imaging for sentinel lymph node (SLN) biopsy in vulvar cancer and to compare the tracer indocyanine green (ICG) bound to human serum albumin (HSA) versus ICG alone. Women received
Naoko Ueda-Arakawa et al.
American journal of ophthalmology, 157(5), 994-1004 (2014-02-05)
To investigate the choroidal thickness/volume of eyes with reticular pseudodrusen using high-penetration swept-source optical coherence tomography (SS-OCT) and to evaluate the choroidal vasculature changes using en face images. Prospective cross-sectional study. Thirty-eight eyes with reticular pseudodrusen and 14 normal eyes
H M Mathéron et al.
Gynecologic oncology, 131(3), 720-725 (2013-09-21)
Conventional sentinel node (SN) mapping is performed by injecting a radiocolloid followed by lymphoscintigraphy (and SPECT/CT imaging). An extra intraoperative injection with blue dye can then allow for optical identification of the SN. In order to improve the current clinical

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