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Key Documents

05-730

Sigma-Aldrich

Anti-STEP Antibody, clone 23E5

clone 23E5, Upstate®, from mouse

Synonym(s):

Neural-specific protein-tyrosine phosphatase, PTPN5

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

mouse

Quality Level

100

antibody form

purified antibody

antibody product type

primary antibodies

clone

23E5, monoclonal

species reactivity

mouse, rat, human

manufacturer/tradename

Upstate®

technique(s)

immunohistochemistry: suitable
immunoprecipitation (IP): suitable
western blot: suitable

isotype

IgG

NCBI accession no.

NM_019253

UniProt accession no.

P54829

shipped in

dry ice

target post-translational modification

unmodified

Gene Information

human ... PTPN5(84867)

Specificity

STEP61, STEP46, STEP38 and STEP20

Immunogen

Peptide corresponding to amino acids 57-74 of rat STEP46

Application

Anti-STEP Antibody, clone 23E5 is an antibody against STEP for use in IP, WB, IH.
Research Category
Neuroscience
Research Sub Category
Ion Channels & Transporters

Neurodegenerative Diseases

Quality

routinely evaluated by immunoblot on in RIPA lysates from whole rat brain preparations

Target description

~64-66 (doublet) & 46

Physical form

0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide before the addition of glycerol to 30%
Format: Purified
Protein G Purified

Storage and Stability

2 years at -20°C

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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A protein tyrosine phosphatase expressed within dopaminoceptive neurons of the basal ganglia and related structures.
Lombroso, P J, et al.
The Journal of Neuroscience, 13, 3064-3074 (1993)
Jun Chen et al.
The European journal of neuroscience, 29(2), 287-306 (2009-02-10)
Although the mechanisms underlying striatal neurodegeneration are poorly understood, we have shown that striatal pathogenesis may be initiated by high synaptic levels of extracellular dopamine (DA). Here we investigated in rat striatal primary neurons the mobilization of the mitogen-activated protein
Sofía Espinoza et al.
BMC biology, 18(1), 164-164 (2020-11-08)
Cognitive dysfunction (CD) is common among patients with the autoimmune disease systemic lupus erythematosus (SLE). Anti-ribosomal P autoantibodies associate with this dysfunction and have neuropathogenic effects that are mediated by cross-reacting with neuronal surface P antigen (NSPA) protein. Elucidating the
Serena M Dudek et al.
Hippocampus, 33(6), 700-711 (2023-05-09)
Since 1959, the Russian Farm-Fox study has bred foxes to be either tame or, more recently, aggressive, and scientists have used them to gain insight into the brain structures associated with these behavioral features. In mice, hippocampal area CA2 has
Daniel Radzicki et al.
Hippocampus, 33(3), 133-149 (2023-02-11)
Hippocampal area CA2 is a molecularly and functionally distinct region of the hippocampus that has classically been defined as the area with large pyramidal neurons lacking input from the dentate gyrus and the thorny excrescences (TEs) characteristic of CA3 neurons.
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