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SAB4200345

Sigma-Aldrich

Anti-SMAD7 antibody produced in rabbit

~1.0 mg/mL, affinity isolated antibody

Synonym(s):

SMAD7 Antibody - Anti-SMAD7 antibody produced in rabbit, Smad7 Antibody, Anti-MADH7, Anti-MADH8, Anti-SMAD family member 7

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About This Item

UNSPSC Code:
12352203
Human Protein Atlas Number:
NACRES:
NA.41

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen ~46 kDa

species reactivity

human, mouse, rat, bovine, monkey

concentration

~1.0 mg/mL

technique(s)

indirect immunofluorescence: 5-10 μg/mL using human A549 cells.
western blot: 2-4 μg/mL using whole extracts of HEK-293 cells over-expressing human SMAD7

UniProt accession no.

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... SMAD7(4092)
mouse ... Smad7(17131)
rat ... Smad7(81516)

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General description

SMAD7 (mothers against decapentaplegic homolog 7) is a Tbx1 (T-box 1) interacting gene and is encoded by the gene mapped to human chromosome 18q21.1.

Immunogen

peptide corresponding to an internal region of human SMAD7, conjugated to KLH. The corresponding sequence is identical in monkey, mouse, rat and bovine

Application

Anti-SMAD7 has been used in western blot analysis and immunofluorescence.

Biochem/physiol Actions

SMAD7 (mothers against decapentaplegic homolog 7) is a modulator of TGFβ (transforming growth factorβ) signaling in immune cells which are associated with ulcerative colitis and inflammatory bowel syndrome. It plays a major role in the etiology of CRC (colorectal cancer). In addition, it also acts as a mediator of the negative feedback loop for both the TGFβ and BMP (bone morphogenetic proteins) signaling pathways. It is essential for the remodelling of pharyngeal artery and the enlargement of great vessel. In mouse, homozygous removal of Smad7 causes primarily fourth-related arch artery defects. Silencing of Smad7 in RCD (refractory coeliac disease) biopsy samples can decrease the expression of interleukin-6 and tumour necrosis factor-α. Polymorphism of this gene is associated with colorectal cancer. SMAD7 is an inhibitor of the TGFβ (transforming growth factor beta) /BMP (bone morphogenetic proteins) pathway.

Physical form

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Protective effect of diltiazem on myocardial ischemic rats induced by isoproterenol
<BIG>Wei Y, et al. </BIG>
Molecular Medicine Reports, 17, 495-501 (2018)
Sodium tanshinone IIA sulfonate attenuates the transforming growth factor-?1-induced differentiation of atrial fibroblasts into myofibroblasts in vitro
Yang L
International Journal of Molecular Medicine, 35, 1026-1032 (2015)
Multiple functional risk variants in a SMAD7 enhancer implicate a colorectal cancer risk haplotype.
Fortini BK
PLoS ONE, 9 (2014)
Zhonglin Li et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 38(4), e23491-e23491 (2024-02-16)
According to recent research, metabolic-associated fatty liver disease (MAFLD) has emerged as an important underlying etiology of hepatocellular carcinoma (HCC). However, the molecular mechanism of MAFLD-HCC is still unclear. Tumor necrosis factor receptor-associated factor 2 (TRAF2) is the key molecule
Intronic polymorphisms of the SMAD7 gene in association with colorectal cancer.
Damavand B
Asian Pacific Journal of Cancer Prevention, 16, 41-44 (2015)

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