4.80448

Acetonitrile solution

HPLC grade, suitable for HPLC, LiChrosolv^®, contains 0.1% (v/v) trifluoroacetic acid

• Synonym(s): Acetonitrile solution, ACN, ACN + TFA, Cyanomethane, Ethyl nitrile, Methyl cyanide
• Linear Formula: CH₃CN
• CAS Number: 75-05-8
• Molecular Weight: 41.05
• Beilstein: 4124158
• MDL number: MFCD00001878
• UNSPSC Code: 12191502
• NACRES: NA.03

Properties

• product name: Acetonitrile with 0.1% (v:v) trifluoroacetic acid, for liquid chromatography LiChrosolv^®
• grade: HPLC grade; isocratic
• Quality Level: 100
• vapor pressure: 97 hPa ( 20 °C)
• product line: LiChrosolv^®
• form: liquid
• concentration: 0.095-0.105 % (v/v) (trifluoroacetic acid)
• technique(s): HPLC: suitable
• transition temp: flash point 2 °C (Acetonitrile)
• density: 0.782 g/mL at 25 °C
• format: mixture
• storage temp.: 2-30°C
• SMILES string: CC#N
• InChI: 1S/C2H3N/c1-2-3/h1H3
• InChI key: WEVYAHXRMPXWCK-UHFFFAOYSA-N

Description

General description

With their high degree of UV transmittance, low particle count, low acidity and alkalinity and low evaporation residue level, LiChrosolv solvents are ideal for reproducible separations. Since separations are normally carried out under gradient conditions in analytical HPLC, we offer solvents in "gradient grade" as well as "isocratic grade". This enables to minimize the gradient effect of the solvent involved.

Application

• Retention time prediction for post-translationally modified peptides: Ser, Thr, Tyr-phosphorylation.: This study presents a methodology for predicting retention times of phosphorylated peptides using high-performance liquid chromatography (HPLC) (Battellino et al., 2024).


• Development and validation of a UPLC-PDA method for quantifying ceftazidime in dried blood spots.: This paper outlines a validated ultra-performance liquid chromatography photodiode array (UPLC-PDA) method for the quantification of ceftazidime, demonstrating its application and accuracy in analyzing dried blood samples (Lv et al., 2024).


• A facile fabric phase sorptive extraction method for monitoring chloramphenicol residues in milk samples.: Describes a new method using fabric phase sorptive extraction for the efficient monitoring of chloramphenicol in milk, highlighting its simplicity and effectiveness (Ben Ayed et al., 2024).


• Study of sample preparation influence on bacterial lipids profile in matrix-assisted laser desorption/ionization time-of-flight mass spectrometry.: This research investigates how different sample preparation methods affect the lipid profiles of bacteria analyzed by MALDI-TOF MS, providing insights into optimizing protocols for better accuracy (Arendowski et al., 2024).


• Simple and robust LC-MS/MS method for quantification of colistin methanesulfonate and colistin in human plasma for therapeutic drug monitoring.: This article details a robust and straightforward liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for the simultaneous determination of colistin methanesulfonate and colistin in human plasma, useful in clinical settings (Kim et al., 2023).

Analysis Note

Assay (trifluoroacetic acid): 0.095 - 0.105 % (v/v)
Lotnumber (trifluoroacetic acid):
Lotnumber (acetonitrile):
Required quantity (trifluoroacetic acid):
Required quantity (acetonitrile):

Other Notes

Explore various lab safety accessories and equipment for safe handling of solvents to increase your safety level from the first usage.

Legal Information

LICHROSOLV is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Pictograms: GHS02,GHS07
• Signal Word: Danger
• Hazard Statements: H225 - H302 + H312 + H332 - H319
• Precautionary Statements: P210 - P280 - P301 + P312 - P303 + P361 + P353 - P304 + P340 + P312 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Flam. Liq. 2
• Storage Class Code: 3 - Flammable liquids
• WGK: WGK 2
• Flash Point(F): 35.6 °F - (Acetonitrile)
• Flash Point(C): 2 °C - (Acetonitrile)