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05-916

Sigma-Aldrich

Anti-P-Cadherin Antibody, clone 6A9

ascites fluid, clone 6A9, Upstate®

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.43

biological source

mouse

Quality Level

antibody form

ascites fluid

antibody product type

primary antibodies

clone

6A9, monoclonal

species reactivity

human

manufacturer/tradename

Upstate®

technique(s)

immunocytochemistry: suitable
immunoprecipitation (IP): suitable
western blot: suitable

NCBI accession no.

UniProt accession no.

shipped in

dry ice

target post-translational modification

unmodified

Gene Information

human ... CDH3(1001)

Specificity

Recognizes P-Cadherin

Immunogen

P-Cadherin extracellular domain purified from A431 cell membranes.

Application

This Anti-P-Cadherin Antibody, clone 6A9 is validated for use in IP, WB, IC for the detection of P-Cadherin.

Quality

Routinely evaluated by immunoblot on A431 cell lysates.

Target description

Mr 120kDa

Analysis Note

Control
Positive Antigen Control: Catalog #12-301, non-stimulated A431 cell lysate. Add 2.5µL of 2-mercaptoethanol/100µL of lysate and boil for 5 minutes to reduce the preparation. Load 20µg of reduced lysate per lane for minigels.

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

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Storage Class Code

10 - Combustible liquids

WGK

WGK 1


Certificates of Analysis (COA)

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M D Hines et al.
Journal of cell science, 112 ( Pt 24), 4569-4579 (1999-11-27)
Cadherin function is required for normal keratinocyte intercellular adhesion and stratification. In the present study, we have investigated whether cadherin-cadherin interactions may also modulate keratinocyte differentiation, as evidenced by alterations in the levels of several differentiation markers. Confluent keratinocyte cultures
Cadherin function is required for human keratinocytes to assemble desmosomes and stratify in response to calcium
Lewis, J. E., et al
The Journal of Investigative Dermatology, 102, 870-877 (1994)
Differential displacement of classical cadherins by VE-cadherin
Jaggi, M., et al
Cell communication & adhesion, 9, 103-115 (2002)
K A Knudsen et al.
Human pathology, 31(8), 961-965 (2000-09-15)
Breast cancers often show reduced expression of the transmembrane cell-cell adhesion protein, E-cadherin. In addition, approximately half of breast carcinomas express P-cadherin, which correlates with poor survival. A large fragment of the E-cadherin extracellular domain can be detected in serum
Gabriel Kolle et al.
Stem cells (Dayton, Ohio), 27(10), 2446-2456 (2009-08-04)
Surface marker expression forms the basis for characterization and isolation of human embryonic stem cells (hESCs). Currently, there are few well-defined protein epitopes that definitively mark hESCs. Here we combine immunotranscriptional profiling of hESC lines with membrane-polysome translation state array

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