- Aptamer-targeted hyperbranched polymers: towards greater specificity for tumours in vivo.
Aptamer-targeted hyperbranched polymers: towards greater specificity for tumours in vivo.
Chemical communications (Cambridge, England) (2013-02-19)
Daniel J Coles, Barbara E Rolfe, Nathan R B Boase, Rakesh N Veedu, Kristofer J Thurecht
PMID23416971
ABSTRACT
Hyperbranched polymers conjugated to a peptide-aptamer were prepared using a combination of RAFT polymerisation and click chemistry for targeting tumour cells in vivo. The polymers showed enhanced cell-uptake in vitro (compared to unconjugated polymer) while excellent specificity for solid tumours was observed in vivo using a mouse model of melanoma.
MATERIALS