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  • [1.6% peppermint oil solution as intestinal spasmolytic in retrograde endoscopic cholangiopancreatography].

[1.6% peppermint oil solution as intestinal spasmolytic in retrograde endoscopic cholangiopancreatography].

Farmacia hospitalaria : organo oficial de expresion cientifica de la Sociedad Espanola de Farmacia Hospitalaria (2011-12-06)
N Solà-Bonada, A M de Andrés-Lázaro, M Roca-Massa, J M Bordas-Alsina, C Codina-Jané, J Ribas-Sala
ABSTRACT

Intestinal peristalsis can impede explorations and interventions using retrograde endoscopic cholangiopancreatography. Systemic spasmolytics are frequently employed to reduce this phenomenon, in spite of the adverse anti-cholinergic effects they are associated with. We proposed a formula using 1.6% peppermint oil solution with local use in order to avoid these adverse side effects. We formulated a preparation of 1.6% peppermint oil solution in accordance with the medical literature. The effectiveness of the formula was evaluated in a semi-qualitative manner according to the reduction in peristalsis. We tested two different emulgents, and polysorbate provided the best results. The pilot study carried out with 8 patients demonstrated its effectiveness and safety in reducing intestinal peristalsis. 1.6% peppermint oil solution constitutes an effective and safe alternative to the use of systemic spasmolytics. More studies are needed with a larger sample size in order to establish its usefulness in normal clinical practice.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Peppermint oil, natural, FCC, FG
Sigma-Aldrich
Peppermint oil, terpeneless, FCC
Sigma-Aldrich
Peppermint oil, natural, from Mentha piperita L.
Sigma-Aldrich
Peppermint oil, purified by triple-distillation, FCC, FG