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110M-1

Sigma-Aldrich

CD10 (56C6) Mouse Monoclonal Antibody

clone 56C6, unconjugated, Cell Marque™

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

mouse

Quality Level

100
500

conjugate

unconjugated

antibody form

culture supernatant

antibody product type

primary antibodies

clone

56C6, monoclonal

description

For In Vitro Diagnostic Use in Select Regions (See Chart)

form

buffered aqueous solution

species reactivity

human

packaging

vial of 0.1 mL concentrate (110M-14)
vial of 0.5 mL concentrate (110M-15)
bottle of 1.0 mL predilute (110M-17)
vial of 1.0 mL concentrate (110M-16)
bottle of 7.0 mL predilute (110M-18)

manufacturer/tradename

Cell Marque™

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:10-1:50

isotype

IgG1

control

kidney, tonsil

shipped in

wet ice

storage temp.

2-8°C

visualization

cytoplasmic, membranous

Gene Information

human ... MME(4311)

Related Categories

General description

CD10, common acute lymphoblastic leukemia antigen, is expressed by a subset of T follicularhelper cells. CD10 has a direct role in cell growth and apoptosis and has been implicated intumor cells proliferation.3 CD10 expression has been reported in a variety of tissues; includingrenal cell carcinoma, hepatocellular carcinoma, and follicular lymphoma.

Quality


IVD
IVD
IVD
RUO

Linkage

CD10 Positive Control Slides, Product No. 110S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

Preparation Note

Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.

Other Notes

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Legal Information

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany

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Certificates of Analysis (COA)

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Ankur R Sangoi et al.
Advances in anatomic pathology, 17(6), 377-393 (2010-10-23)
The diagnosis of metastatic clear cell renal cell carcinoma may be difficult in some cases, particularly in the small image-guided biopsies that are becoming more common. As targeted therapies for renal cell carcinoma are now standard treatment, the recognition and
W G McCluggage et al.
Histopathology, 39(3), 273-278 (2001-09-05)
The CD10 antigen is expressed in acute lymphoblastic leukaemia and follicle centre cell lymphoma. A recent study investigating the expression of CD10 in a wide range of non-haematopoietic neoplasms found positive staining in a small number of endometrial stromal sarcomas
Swerdlow S, et al. WHO classification of tumours of hematopoietic and lymphoid tissues. 4th edition. 2008. P. 220,233,255,265,309.
WHO Classification of Tumours of Haematopoietic and Lymphoid Tissue, 220-220 (2008)
A D Attygalle et al.
Histopathology, 50(4), 498-508 (2007-04-24)
To identify distinguishing histological, immunophenotypic and molecular genetic features between angioimmunoblastic T-cell lymphoma (AITL) and peripheral T-cell lymphoma (PTL). Nodal T-cell lymphomas examined (n =137), included AITL (n = 89), PTL (n = 22), anaplastic large cell lymphoma (n =
Swerdlow S, et al. WHO classification of tumours of hematopoietic and lymphoid tissues. 4th edition. 2008. P. 220,233,255,265,309.
WHO Classification of Tumours of Haematopoietic and Lymphoid Tissue, 220-220 (2008)
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