554324
Phenylacetyl disulfide
96%
Synonym(s):
Bis(phenylacetyl) disulfide, Di(phenylacetyl) disulfide
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About This Item
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Assay
96%
form
solid
mp
59-63 °C (lit.)
SMILES string
O=C(Cc1ccccc1)SSC(=O)Cc2ccccc2
InChI
1S/C16H14O2S2/c17-15(11-13-7-3-1-4-8-13)19-20-16(18)12-14-9-5-2-6-10-14/h1-10H,11-12H2
InChI key
IXGZXXBJSZISOO-UHFFFAOYSA-N
General description
Phenylacetyl disulphide serves as a sulfurization reagent during the preparation of phosphates.Phenyl acetyl disulfide can be synthesized by the reaction of phenyl benzenethiolsulfonate with thioacetic acid in the presence of triethylamine.
Application
Phenylacetyl disulfide (PADS) may be used as a sulphur transfer agent during the synthesis of phosphorothioate oligodeoxyribonucleotides.
Storage Class Code
11 - Combustible Solids
WGK
WGK 2
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Certificates of Analysis (COA)
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"Organic disulfides and related substances. XXIII. Unsymmetrical carbonyl disulfides and cognate compounds"
The Journal of Organic Chemistry, 32(11), 3467-3470 (1967)
A study on the use of phenylacetyl disulfide in the solid-phase synthesis of oligodeoxynucleoside phosphorothioates.
J. R. Neth. Chem. Soc., 110(7-8), 325-331 (1991)
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Use of phenylacetyl disulfide (PADS) in the synthesis of oligodeoxyribonucleotide phosphorothioates.
Nucleosides, nucleotides & nucleic acids, 18(3), 485-492 (1999)
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