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  • High-Throughput Reaction Screening with Nanomoles of Solid Reagents Coated on Glass Beads.

High-Throughput Reaction Screening with Nanomoles of Solid Reagents Coated on Glass Beads.

Angewandte Chemie (International ed. in English) (2019-03-21)
Noah P Tu, Amanda W Dombrowski, Gashaw M Goshu, Anil Vasudevan, Stevan W Djuric, Ying Wang
ABSTRACT

Technologies that enable rapid screening of diverse reaction conditions are of critical importance to methodology development and reaction optimization, especially when molecules of high complexity and scarcity are involved. The lack of a general solid dispensing method for chemical reagents on micro- and nanomole scale prevents the full utilization of reaction screening technologies. We herein report the development of a technology in which glass beads coated with solid chemical reagents (ChemBeads) enable the delivery of nanomole quantities of solid chemical reagents efficiently. By exploring the concept of preferred screening sets, the flexibility and generality of this technology for high-throughput reaction screening was validated.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
AdBrettPhos ChemBeads
Sigma-Aldrich
Lithium hydroxide ChemBeads
SPhos Pd G2 ChemBeads
Sigma-Aldrich
DPPF Pd G4 ChemBeads
Sigma-Aldrich
(t-Bu)PhCPhos Pd G4 ChemBeads
Sigma-Aldrich
RuPhos Pd G2 Chembeads
Sigma-Aldrich
QPhos Pd G3 ChemBeads
Sigma-Aldrich
GPhos Pd G3 ChemBeads
Sigma-Aldrich
MorDalPhos Pd G4 ChemBeads
Sigma-Aldrich
tBuXPhos ChemBeads
N-XantPhos Pd G4 ChemBeads
Sigma-Aldrich
Copper(I) Chloride ChemBeads, 15 wt% loading
Sigma-Aldrich
DPPF ChemBeads
Sigma-Aldrich
[1,1′-Bis(diphenylphosphino)ferrocene]dichloropalladium(II) ChemBeads
Sigma-Aldrich
PCy3 Pd G4 ChemBeads
Sigma-Aldrich
Sodium tert-butoxide ChemBeads
Sigma-Aldrich
Potassium hexachloroplatinate(IV) CHEMBEADS
Sigma-Aldrich
Josiphos SL-J009-1 Pd G3 ChemBeads
Sigma-Aldrich
SPhos Pd G3 ChemBeads
Sigma-Aldrich
Palladium(II) Acetate ChemBeads
Sigma-Aldrich
RuPhos ChemBeads
Sigma-Aldrich
P(t-Bu)3 Pd G4 ChemBeads
Sigma-Aldrich
Postassium hydroxide ChemBeads
Sigma-Aldrich
BrettPhos Pd G4 ChemBeads
Sigma-Aldrich
SPhos Pd G4 ChemBeads
Sigma-Aldrich
DTBPF Pd G3 ChemBeads
Sigma-Aldrich
XantPhos Pd G4 ChemBeads
Sigma-Aldrich
tBuBrettPhos ChemBeads
Sigma-Aldrich
Sodium phosphate ChemBeads
Sigma-Aldrich
Palladium(II) chloride ChemBeads