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T6442

Sigma-Aldrich

Anti-TRPC6 antibody produced in rabbit

affinity isolated antibody, lyophilized powder

Synonym(s):

Anti-Transient receptor potential cation channel, subfamily C, member 6 antibody produced in rabbit

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About This Item

MDL number:
MFCD02686669
UNSPSC Code:
12352203
NACRES:
NA.41

biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

lyophilized powder

species reactivity

mouse, rat

technique(s)

immunohistochemistry: suitable using mouse brain sections
western blot: 1:200-1:400 using rat brain or lung lysates

UniProt accession no.

Q61143

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... TRPC6(7225)
mouse ... Trpc6(22068)
rat ... Trpc6(89823)

Immunogen

synthetic peptide (RRNESQDYLLMDELG) corresponding to amino acids residues 24-38 of mouse TRPC6. This sequence is identical in rat and highly homologous (15/16 residues identical) in human.

Physical form

Lyophilized from phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin, and 0.05% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Yonghong Bai et al.
eLife, 9 (2020-03-10)
Transient receptor potential canonical (TRPC) proteins form nonselective cation channels that play physiological roles in a wide variety of cells. Despite growing evidence supporting the therapeutic potential of TRPC6 inhibition in treating pathological cardiac and renal conditions, mechanistic understanding of
Chengkang He et al.
JCI insight, 7(5) (2022-01-26)
Currently, the most effective strategy for dealing with Alzheimer's disease (AD) is delaying the onset of dementia. Severe hypoglycemia is strongly associated with dementia; however, the effects of recurrent moderate hypoglycemia (RH) on the progression of cognitive deficits in patients
Ying Meng et al.
International journal of molecular medicine, 37(1), 258-266 (2016-01-01)
Ischemia-reperfusion (I/R) plays an important role in myocardial injury. In the present study, we aimed to examine the protective effects of Danshensu (DSS) against I/R injury and to elucidate the underlying mechanisms. For this purpose, H9c2 cells were cultured in hypoxic solution
Yanna Du et al.
Molecular medicine reports, 16(2), 1117-1124 (2017-06-20)
Persistent pulmonary hypertension of the newborn (PPHN) is a life‑threatening disease that is commonly observed in the neonatal intensive care unit. PPHN is pathologically characterized by pulmonary vascular remodeling and, in particular, pulmonary artery smooth muscle cell (PASMC) proliferation. Decreased
M Salomonsson et al.
Acta physiologica (Oxford, England), 200(3), 265-278 (2010-04-30)
In rat afferent arterioles we investigated the role of Na(+) entry in noradrenaline (NA)-induced depolarization and voltage-dependent Ca(2+) entry together with the importance of the transient receptor potential channel (TRPC) subfamily for non-voltage-dependent Ca(2+) entry. R (340/380) Fura-2 fluorescence was
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