Skip to Content
Merck
All Photos(2)

Key Documents

G3643

Sigma-Aldrich

α1-Acid Glycoprotein from bovine plasma

≥99%

Synonym(s):

Orosomucoid

Sign Into View Organizational & Contract Pricing
All Photos(2)

About This Item

CAS Number:
66455-27-4
MDL number:
MFCD00131224
UNSPSC Code:
12352202
NACRES:
NA.61

biological source

bovine plasma

Assay

≥99%

form

powder

technique(s)

electrophoresis: suitable
mass spectrometry (MS): suitable

UniProt accession no.

Q3SZR3

storage temp.

2-8°C

Gene Information

bovine ... ORM1(497200)

Looking for similar products? Visit Product Comparison Guide

General description

α1-Acid Glycoprotein (AGP, orosomucoid) from bovine plasma belongs to ‘lipocalins′ family which binds and transports small hydrophobic molecules. AGP is further classified into the subfamily ‘immunocalins′ which immunomodulates the inflammatory reactions. AGP is primarily produced in the liver, in few extra hepatic tissues and is present in neutrophil granules. Healthy cattle possesses 0.3 mg of AGP/ ml of concentrated serum.
α1-Acid glycoprotein (AGP, orosomucoid) is the major plasma glycoprotein with a molecular weight of 41-43 kDa. It is responsible for possessing the complex type of glycans.

Application

α1-Acid Glycoprotein (AGP) from bovine plasma has been used:
  • in mass spectrometry analysis to confirm the presence of Neu5Ac and Neu5Gc distribution in human and bovine AGP respectively
  • for pretreating the microvessel before perfusing the MDA-MB-231 cells for tumor adhesion studies
  • in the composition of tear model
  • as a reference in sodium dodecyl sulphate-polyacrylamide gel electrophoresis (SDS-PAGE)

α1-Acid glycoprotein was used to study nonviral gene delivery to the lung with copolymer-protected and transferrin-modified polyethylenimine

Biochem/physiol Actions

α1-Acid Glycoprotein from bovine plasma is an acute phase protein. It has anti-inflammatory potential and its concentration increases several folds during injury. AGP increases the chemotactic activity and life span of monocytes and inhibits neutrophil degranulation. Serum AGP levels differentiates sepsis from systemic inflammatory response syndrome (SIRS).

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

C Rudolph et al.
Biochimica et biophysica acta, 1573(1), 75-83 (2002-10-18)
Polyethylenimine (PEI) has been shown to efficiently mediate topical gene transfer to the lungs after either direct intratracheal instillation or nebulisation. Recently, the protection of polyplexes with novel copolymers of poly(ethylene glycol) (PEG) via electrostatic interaction has been reported. In
Identification of the bovine alpha1-acid glycoprotein in colostrum and milk
Ceciliani F, et al.
Veterninary Research, 36(5-6), 735-746 (2005)
alpha-1-Acid glycoprotein as a biomarker for the early diagnosis and monitoring the prognosis of sepsis
Xiao K, et al.
Journal of Critical Care, 30(4), 744-751 (2015)
Adhesion of malignant mammary tumor cells MDA-MB-231 to microvessel wall increases microvascular permeability via degradation of endothelial surface glycocalyx
Cai B, et al.
Journal of Applied Physiology, 113(7), 1141-1153 (2012)
Christopher J Day et al.
Scientific reports, 7(1), 1495-1495 (2017-05-06)
Subtilase cytotoxin (SubAB) of Escherichia coli is an AB5 class bacterial toxin. The pentameric B subunit (SubB) binds the cellular carbohydrate receptor, α2-3-linked N-glycolylneuraminic acid (Neu5Gc). Neu5Gc is not expressed on normal human cells, but is expressed by cancer cells.
View All Related Papers

Articles

Rapid Glycan Prep & Analysis by LC-MS Workflow

PNGase Fast denaturing buffer and enzyme provide results similar to a conventional 20-hour protocol, reducing workflow time to about 1 hour.

Rapid Glycan Prep & Analysis by LC-MS Workflow

PNGase Fast denaturing buffer and enzyme provide results similar to a conventional 20-hour protocol, reducing workflow time to about 1 hour.

Rapid Glycan Prep & Analysis by LC-MS Workflow

PNGase Fast denaturing buffer and enzyme provide results similar to a conventional 20-hour protocol, reducing workflow time to about 1 hour.

Rapid Glycan Prep & Analysis by LC-MS Workflow

PNGase Fast denaturing buffer and enzyme provide results similar to a conventional 20-hour protocol, reducing workflow time to about 1 hour.

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service