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BCR265

Dibenzo[a,e]fluoranthene

BCR®, certified reference material

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About This Item

Empirical Formula (Hill Notation):
C24H14
CAS Number:
5385-75-1
Molecular Weight:
302.37
Beilstein:
2120920
MDL number:
MFCD00215892
UNSPSC Code:
41116107
PubChem Substance ID:
329773799
NACRES:
NA.24

grade

certified reference material

Agency

BCR®

manufacturer/tradename

JRC

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

format

neat

storage temp.

2-8°C

SMILES string

c1ccc-2c(c1)-c3cc4ccccc4c5cc6ccccc6c-2c35

InChI

1S/C24H14/c1-3-9-17-15(7-1)13-22-19-11-5-6-12-20(19)23-18-10-4-2-8-16(18)14-21(17)24(22)23/h1-14H

InChI key

JHOWUOKQHJHGMU-UHFFFAOYSA-N

Analysis Note

For more information please see:
BCR265

Legal Information

BCR is a registered trademark of European Commission

Pictograms

Health hazard
GHS08

Signal Word

Warning

Hazard Statements

H351

Precautionary Statements

P201 - P308 + P313

Hazard Classifications

Carc. 2

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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O Perin-Roussel et al.
Cancer letters, 36(2), 169-180 (1987-08-01)
The production by dibenzo[a,e]fluoranthene (DBF) of DNA-protein cross-links in cultured mouse fibroblasts is probably mediated by the activation of proximate metabolites of DBF and not by the DBF molecule itself. In order to test this hypothesis, several agents that enhance
F Zajdela et al.
Carcinogenesis, 8(3), 461-464 (1987-03-01)
Dibenzofluoranthene-12,13-dihydrodiol (DBF-12,13-DHD) is six times more mutagenic in Salmonella TA100 than dibenzofluoranthene-3,4-dihydrodiol (DBF-3,4-DHD). However, these two major dibenzo[a,e]fluoranthene (DBF) proximate metabolites, which are immediate precursors of the corresponding diolepoxides, showed on an equimolar basis nearly identical initiation activities on mouse
Metabolic activation of dibenzo(a,e)fluoranthene, a nonalternant carcinogenic polycyclic hydrocarbon, in liver homogenates.
O Perin-Roussel et al.
Cancer research, 40(5), 1742-1749 (1980-05-01)
O Périn-Roussel et al.
Carcinogenesis, 9(8), 1383-1388 (1988-08-01)
The three-dimensional distribution of nuclear DNA damage induced by dibenzo(a,e)fluoranthene (DBF), a potent carcinogen for mouse fibroblasts, has been examined. The intact supercoiled nuclear DNA obtained from nucleoids of mouse fibroblasts incubated with DBF was fractionated into loop DNA attached
O Perin-Roussel et al.
Chemico-biological interactions, 37(1-2), 109-122 (1981-10-01)
The effects of norharman (NH) on the metabolism of dibenzo[a,e]-fluoranthene (DBF) and on its fixation on DNA, RNA and proteins have been studied in vitro by incubation with S-9 and microsomes from rats and mice. NH causes a decrease of
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