15523-M

Glycerol

puriss., meets analytical specification of Ph. Eur., BP, USP, FCC, E422, anhydrous, 99.0-101.0% (alkalimetric)

• Synonym(s): 1,2,3-Propanetriol, Glycerin
• Linear Formula: HOCH₂CH(OH)CH₂OH
• CAS Number: 56-81-5
• Molecular Weight: 92.09
• Beilstein: 635685
• EC Number: 200-289-5
• MDL number: MFCD00004722
• UNSPSC Code: 12352104
• PubChem Substance ID: 329750924
• NACRES: NA.21

Properties

• Agency: meets analytical specifications of BP; meets analytical specifications of E422; meets analytical specifications of Ph. Eur.; meets analytical specifications of USP
• Quality Level: 100
• reg. compliance: meets analytical specifications of FCC
• vapor density: 3.1 (vs air)
• vapor pressure: <1 mmHg ( 20 °C)
• grade: puriss.
• Assay: 99.0-101.0% (alkalimetric); 99.0-101.0% (calc. on H₂O free substance)
• form: liquid
• autoignition temp.: 698 °F
• quality: meets analytical specification of Ph. Eur., BP, USP, FCC, E422
• technique(s): IR spectroscopy: suitable; electrophoresis: suitable
• impurities: acidity or alkalinity, complies; acrolein, glucose and NH₄-compounds, complies; ester, complies; fatty acids and esters, complies; impurities A and related substances (GC), complies; residual solvents, complies; sugar, complies; ≤0.003% free acid (as CH₃COOH); ≤0.2% 1,2,4-butantriole (GC); ≤10 ppm aldehydes (as HCHO); ≤2% water (Karl Fischer); ≤30 ppm halogen compounds (as Cl); ≤5 ppm heavy metals (as Pb)
• ign. residue: ≤0.01% (as SO₄)
• refractive index: n20/D 1.471-1.474; n20/D 1.474 (lit.)
• pH: 5.5-8
• bp: 182 °C/20 mmHg (lit.)
• mp: 20 °C (lit.)
• density: 1.2580-1.2644 g/mL at 20 °C; ≥1.257 g/mL at 25 °C; 1.25 g/mL (lit.)
• SMILES string: OCC(O)CO
• anion traces: chloride (Cl^-): ≤10 ppm; sulfate (SO₄^2-): ≤10 ppm
• cation traces: As: ≤1 ppm; Cu: ≤0.001%; Pb: ≤1 ppm; Zn: ≤0.001%
• suitability: complies for appearance of solution; complies for reaction against H₂SO₄; corresponds for chromatography; passes test for identity (IR)
• InChI: 1S/C3H8O3/c4-1-3(6)2-5/h3-6H,1-2H2
• InChI key: PEDCQBHIVMGVHV-UHFFFAOYSA-N

Description

General description

Glycerol is odourless, colorless, viscous in nature, and exists as a sweet tasting liquid. It can be derived naturally as well as from petrochemical feedstock. Glycerol has a wide variety of applications, and is one of the most valuable and versatile chemical substances in nature. It can be used as an emollient, solvent, sweetening agent, in pharmaceutical formulations, cosmetics, foodstuffs and toiletries. It is very stable and can be easily stored under normal temperature; also it is non-irritating and has no adverse impact to the environment.

Biochem/physiol Actions

Glycerol has been used as

• a supplement during cell culture of Mycobacterium tuberculosis and Mycobacterium avium.
• a fuel during designing enzymatic biofuel cell.
• a liquid composite matrix with 4-HCCA and 3-amino­quinoline for analysis of neutral and acidic glycans.
• a matrix for fast atom bombardment MS.
• may be employed as liquid matrix for the quantification studies by MALDI (Matrix-assisted laser desorption/ionization mass spectrometry) analysis.

Glycerol is hygroscopic in nature and is soluble in water owing to its three hydrophilic alcoholic hydroxyl groups. It can form both inter- and intramolecular hydrogen bonds, making it a very flexible molecule. The physiologic effect of glycerine is due to cell-mediated immunity, increased IgG production and increased histamine release.

Safety Information

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 1
• Flash Point(F): 320.0 °F - closed cup
• Flash Point(C): 160 °C - closed cup