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8.06722

Sigma-Aldrich

Nickel(II) chloride

anhydrous for synthesis

Synonym(s):

Nickel(II) chloride, Nickel dichloride

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About This Item

Empirical Formula (Hill Notation):
Cl2Ni
CAS Number:
7718-54-9
Molecular Weight:
129.60
UNSPSC Code:
12352302
EC Index Number:
231-743-0
NACRES:
NA.22

vapor pressure

1.33 hPa ( 671 °C)

Quality Level

200

form

powder

potency

105 mg/kg LD50, oral (Rat)

pH

4 (20 °C, 500 g/L in H2O)

mp

1009 °C

density

3.55 g/cm3

storage temp.

2-30°C

InChI

1S/2ClH.Ni/h2*1H;/q;;+2/p-2

InChI key

QMMRZOWCJAIUJA-UHFFFAOYSA-L

Application

Nickel(II) chloride can be used as a catalyst:
  • To synthesize acyclic and cyclic dithioacetals via thioacetalization of aldehydes.
  • To prepare α-aminonitrile derivatives via a one-pot, three-component coupling reaction of aldehydes, amines, and trimethylsilyl cyanide.
  • In the hydrodefluorination of fluoroarenes in the presence of lithium triethylborohydride.

Analysis Note

Assay (complexometric): 98.0 - 102.0 %
Loss on drying (150 °C; 3h): ≤ 1.0 %

Signal Word

Danger

Hazard Classifications

Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 1A Inhalation - Muta. 2 - Repr. 1B - Resp. Sens. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT RE 1 Inhalation

Target Organs

Lungs

Storage Class Code

6.1D - Non-combustible, acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

EU REACH Annex XVII (Restriction List)

CAS No.

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Nickel (II) chloride as an efficient and useful catalyst for chemoselective thioacetalization of aldehydes
Khan AT, et al.
Tetrahedron Letters, 44(5), 919-922 (2003)
Highly Efficient Nickel (II) Chloride/Bis (tricyclohexylphosphine) nickel (II) Chloride-Cocatalyzed Hydrodefluorination of Fluoroarenes and Trifluorotoluenes with Superhydride
Zhao Wenwen, et al.
advanced synthesis and catalysis, 354(4), 574-578 (2012)
Highly Efficient Nickel (II) Chloride/Bis (tricyclohexylphosphine) nickel (II) Chloride-Cocatalyzed Hydrodefluorination of Fluoroarenes and Trifluorotoluenes with Superhydride
Zhao Wenwen, et al.
Advanced Synthesis & Catalysis, 354(4), 574-578 (2012)
Nickel (II) chloride catalyzed one-pot synthesis of α-aminonitriles
De Surya Kanta
J. Mol. Catal. A: Chem., 225(2), 169-171 (2005)

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