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  • Novel bacterial molybdenum and tungsten enzymes: three-dimensional structure, spectroscopy, and reaction mechanism.

Novel bacterial molybdenum and tungsten enzymes: three-dimensional structure, spectroscopy, and reaction mechanism.

Biological chemistry (2005-10-13)
Matthias Boll, Bernhard Schink, Albrecht Messerschmidt, Peter M H Kroneck
ABSTRACT

The molybdenum enzymes 4-hydroxybenzoyl-CoA reductase and pyrogallol-phloroglucinol transhydroxylase and the tungsten enzyme acetylene hydratase catalyze reductive dehydroxylation reactions, i.e., transhydroxylation between phenolic residues and the addition of water to a triple bond. Such activities are unusual for this class of enzymes, which carry either a mononuclear Mo or W center. Crystallization and subsequent structural analysis by high-resolution X-ray crystallography has helped to resolve the reaction centers of these enzymes to a degree that allows us to understand the interaction of the enzyme and the respective substrate(s) in detail, and to develop a concept for the respective reaction mechanism, at least in two cases.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Tungsten, powder, 12 μm, 99.9% trace metals basis
Sigma-Aldrich
Tungsten, foil, thickness 0.25 mm, ≥99.9% trace metals basis
Tungsten, insulated wire, 5m, conductor diameter 0.075mm, insulation thickness 0.02mm, PTFE (polytetrafluoroethylene) insulation, 99.9%
Tungsten, insulated wire, 10m, conductor diameter 0.05mm, insulation thickness 0.008mm, polyimide insulation, 99.9%
Tungsten, microfoil, disks, 10mm, thinness 0.25μm, specific density 474μg/cm2, permanent mylar 3.5μm support, 99.95%
Tungsten, insulated wire, 0.2m, conductor diameter 0.015mm, insulation thickness 0.002mm, polyimide insulation, 99.9%
Tungsten, foil, 5m coil, thickness 0.025mm, coil width 1mm, as rolled, 99.95%
Tungsten, insulated wire, 20m, conductor diameter 0.05mm, insulation thickness 0.008mm, polyimide insulation, 99.9%
Tungsten, foil, not light tested, 50x50mm, thickness 0.004mm, 99.95%
Tungsten, foil, light tested, 150x150mm, thickness 0.05mm, as rolled, 99.95%
Tungsten, lump, 200g, max. size 5mm
Tungsten, insulated wire, 2m, conductor diameter 0.075mm, insulation thickness 0.02mm, PTFE (polytetrafluoroethylene) insulation, 99.9%
Tungsten, rod, 200mm, diameter 6.35mm, centerless ground, 99.95%
Tungsten, foil, light tested, 50x50mm, thickness 0.075mm, as rolled, 99.95%
Tungsten, foil, not light tested, 25x25mm, thickness 0.004mm, 99.95%
Tungsten, insulated wire, 2m, conductor diameter 0.025mm, insulation thickness 0.005mm, polyimide insulation, 99.9%
Tungsten, foil, 30mm disks, thickness 1.0mm, as rolled, 99.95%
Tungsten, foil, light tested, 150x150mm, thickness 0.075mm, as rolled, 99.95%
Tungsten, lump, 50g, max. size 5mm
Tungsten, insulated wire, 1m, conductor diameter 0.015mm, insulation thickness 0.002mm, polyimide insulation, 99.9%
Tungsten, microfoil, disks, 10mm, thinness 0.05μm, specific density 96μg/cm2, permanent mylar 3.5μm support, 99.95%
Tungsten, insulated wire, 2m, conductor diameter 0.0125mm, insulation thickness 0.0035mm, polyimide insulation, 99.9%
Tungsten, foil, light tested, 150x150mm, thickness 0.025mm, as rolled, 99.95%
Tungsten, microfoil, disks, 10mm, thinness 0.1μm, specific density 182μg/cm2, permanent mylar 3.5μm support, 99.95%
Tungsten, wire reel, 0.5m, diameter 1.0mm, clean, 99.95%
Tungsten, insulated wire, 2m, conductor diameter 0.015mm, insulation thickness 0.002mm, polyimide insulation, 99.9%
Tungsten, foil, not light tested, 50x50mm, thickness 0.007mm, 99.95%
Tungsten, foil, not light tested, 25x25mm, thickness 0.006mm, 99.95%
Tungsten, rod, 100mm, diameter 5.0mm, centerless ground, 99.95%
Tungsten, mesh, 100x100mm, nominal aperture 0.2mm, wire diameter 0.05mm, 100 wires/inch, open area 64%, plain weave mesh, 99.95%