- Antibacterial alkoxybenzamide inhibitors of the essential bacterial cell division protein FtsZ.
Antibacterial alkoxybenzamide inhibitors of the essential bacterial cell division protein FtsZ.
Bioorganic & medicinal chemistry letters (2008-12-10)
Lloyd G Czaplewski, Ian Collins, E Andrew Boyd, David Brown, Stephen P East, Mihaly Gardiner, Rowena Fletcher, David J Haydon, Vincent Henstock, Peter Ingram, Clare Jones, Caterina Noula, Leanne Kennison, Chris Rockley, Valerie Rose, Helena B Thomaides-Brears, Rebecca Ure, Mark Whittaker, Neil R Stokes
PMID19064318
ABSTRACT
3-Methoxybenzamide is a weak inhibitor of the essential bacterial cell division protein FtsZ. Exploration of the structure-activity relationships of 3-methoxybenzamide analogues led to the identification of potent anti-staphylococcal compounds.