L0881
Lectin from Arachis hypogaea (peanut)
lyophilized powder, Affinity-purified
Synonym(s):
PNA, Peanut agglutinin
Sign Into View Organizational & Contract Pricing
All Photos(2)
About This Item
UNSPSC Code:
12352202
NACRES:
NA.32
Recommended Products
form
lyophilized powder
Quality Level
potency
<0.1 μg per mL agglutination activity
quality
Affinity-purified
impurities
salt, free
storage temp.
−20°C
Looking for similar products? Visit Product Comparison Guide
General description
Lectin from Arachis hypogaea (peanut) is a homotetrameric protein of 110 kDa.
Application
Lectin from Arachis hypogaea (peanut) has been used:
- to detect Thomson-Friedenreich antigen
- as a component in PBS to study its effects on cell viability
- to study its ability to block the binding site
Biochem/physiol Actions
Lectin from Arachis hypogaea (peanut) possess specificity towards β -D-Gal(1-3)-D-galNAc residue of Thomson − Friedenreich antigen. It is the most widely used diagnostic and prognostic marker for many squamous cell carcinomas.
PNA does not agglutinate normal human erythrocytes, but strongly agglutinates neuraminidase treated erythrocytes. PNA has potent anti-T activity similar to the anti-T antibody in human sera. The lectin can be used to distinguish between human lymphocyte subsets.
Analysis Note
Agglutination activity is expressed in μg/ml and is determined from serial dilutions in phosphate buffered saline, pH 6.8, of a 1 mg/ml solution. This activity is the lowest concentration to agglutinate a 2% suspension of neuraminidase treated human blood group O erythrocytes after 1 hr incubation at 25 °C.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Customers Also Viewed
Adhesion of plant roots to poly-L-lysine coated polypropylene substrates
Towler MJ and Weathers PJ
Journal of Biotechnology, 101(2), 147-155 (2003)
Alejandro J Cagnoni et al.
Acta crystallographica. Section D, Structural biology, 76(Pt 11), 1080-1091 (2020-11-03)
Carbohydrate-lectin interactions are involved in important cellular recognition processes, including viral and bacterial infections, inflammation and tumor metastasis. Hence, structural studies of lectin-synthetic glycan complexes are essential for understanding lectin-recognition processes and for the further design of promising chemotherapeutics that
In vivo tumor cell adhesion in the pulmonary microvasculature is exclusively mediated by tumor cell-endothelial cell interaction
Gassmann P
BMC Cancer, 10(1), 177-177 (2010)
In vitro and in vivo antitumor effects of Peanut agglutinin through induction of apoptotic and autophagic cell death
Mukhopadhyay S, et al.
Food And Chemical Toxicology, 64, 369-377 (2014)
Peter Gassmann et al.
BMC cancer, 10, 177-177 (2010-05-04)
Metastasis formation is the leading cause of death among colon cancer patients. We established a new in-situ model of in vivo microscopy of the lung to analyse initiating events of metastatic tumor cell adhesion within this typical metastatic target of
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Contact Technical Service