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B1265

Sigma-Aldrich

Anti-Human IgM (μ-chain specific)−Biotin antibody produced in goat

affinity isolated antibody, buffered aqueous solution

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About This Item

MDL number:
UNSPSC Code:
12352203
NACRES:
NA.46

biological source

goat

Quality Level

conjugate

biotin conjugate

antibody form

affinity isolated antibody

antibody product type

secondary antibodies

clone

polyclonal

form

buffered aqueous solution

technique(s)

direct ELISA: 1:20,000

storage temp.

2-8°C

target post-translational modification

unmodified

General description

Human IgMs are the initial immunoglobulin isotypes that appear in blood in response to the first exposure to external antigens. IgMs have been implicated in CNS myelin repair and increased secretory IgM levels have been linked to rhino-conjunctivitis . Anti-Human IgM (μ-chain specific)-Biotin antibody is specific for human IgM and does not bind other human immunoglobulins.
IgM antibody is produced by B cells and plays a pivotal role in primary defence mechanism. The main function is to recognise and eliminate foreign invaders like bacteria and viruses, cellular waste as well as precancerous and cancerous lesions. Anti-human IgM (μ-chain specific) −biotin antibody can be used in micro ELISA to determine IgD isotype antibody to phosphorylcholine (PC) . Goat anti-human IgM antibodies react specifically with human IgM but not with other human immunoglobulins.

Immunogen

Purified human IgM
Purified human IgM.

Application

Anti-Human IgM (μ-chain specific)-Biotin antibody is suitable for use in ELISA (1:2000) .

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin and 15 mM sodium azide

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

nwg

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


Certificates of Analysis (COA)

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R Tisch et al.
Proceedings of the National Academy of Sciences of the United States of America, 85(18), 6914-6918 (1988-09-01)
Crosslinked IgM molecules expressed on the surface of immature B cells mediate responses that inhibit further development, in contrast to the activational and proliferative events that follow crosslinking of the mu heavy chain in mature B cells. Concomitant with this
Miguel A Trujillo et al.
DNA and cell biology, 22(8), 513-523 (2003-10-21)
We examined the role of BCR cell membrane redistribution in anti-IgM-induced apoptosis in three human B cell lines, RA#1, 2G6, and MC116, that differ in their relative levels of sIgM expression. The apoptotic response was found to be dependent on
A Ripamonti et al.
Proceedings of the National Academy of Sciences of the United States of America, 114(48), 12797-12802 (2017-11-15)
Follicular helper T cells (TFHs) are a key component of adaptive immune responses as they help antibody production by B cells. Differentiation and function of TFH cells are controlled by the master gene BCL6, but it is largely unclear how
Charu Aggarwal et al.
Journal of virology, 95(23), e0061021-e0061021 (2021-09-16)
Plasmablasts represent a specialized class of antibody-secreting effector B cells that transiently appear in blood circulation following infection or vaccination. The expansion of these cells generally tends to be massive in patients with systemic infections such as dengue or Ebola
Bengt Rönnberg et al.
Medical microbiology and immunology, 206(5), 383-401 (2017-08-31)
The recent spread of Zika virus (ZIKV) in the Americas and Asia necessitates an increased preparedness for improved maternal and perinatal health and blood safety. However, serological cross-reactions, especially to Dengue virus (DENV), complicate ZIKV antibody serodiagnosis. A novel "pan-Flavi"

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