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347795

Sigma-Aldrich

Sodium dichloroacetate

98%

Synonym(s):

Dichloroacetic acid sodium salt

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About This Item

Linear Formula:
Cl2CHCO2Na
CAS Number:
2156-56-1
Molecular Weight:
150.92
EC Number:
218-461-3
MDL number:
MFCD00070489
UNSPSC Code:
12352302
PubChem Substance ID:
24861527
NACRES:
NA.22

Quality Level

100

Assay

98%

impurities

<2% ethyl alcohol

mp

198 °C (dec.) (lit.)

SMILES string

[Na+].[O-]C(=O)C(Cl)Cl

InChI

1S/C2H2Cl2O2.Na/c3-1(4)2(5)6;/h1H,(H,5,6);/q;+1/p-1

InChI key

LUPNKHXLFSSUGS-UHFFFAOYSA-M

Gene Information

human ... PDK1(5163) , PDK2(5164) , PDK3(5165) , PDK4(5166)

General description

Sodium dichloroacetate is a mitochondrial pyruvate dehydrogenase kinase (PDK) inhibitor that exhibits potent anti-leukemic activity.

Application

Sodium dichloroacetate can be used as an organic salt precursor for synthesizing microporous carbon that is useful in developing carbon-based adsorbents.

Other Notes

2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research

Pictograms

Health hazardExclamation mark
GHS08,GHS07

Signal Word

Warning

Hazard Statements

H315,H319,H335,H351

Hazard Classifications

Carc. 2 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Peng Wang et al.
Shock (Augusta, Ga.), 49(6), 704-711 (2017-08-29)
No pharmacological interventions are currently available to provide neuroprotection for patients suffering from cardiac arrest. Dichloroacetate (DCA) is a pyruvate dehydrogenase kinase inhibitor, which activates pyruvate dehydrogenase (PDH), and increases cell adenosine triphosphate (ATP) production by promoting influx of pyruvate
Frank Comhaire
Medical hypotheses, 120, 65-67 (2018-09-18)
Myalgic Encephalopathy/Chronic Fatigue Syndrome (ME/CFS) is an enigmatic disease the pathogenesis of which remains elusive. Pragmatic proof-of-principle of the hypothetical mechanisms causing the clinical symptoms has been delivered, but it is hard to explain why some patients do respond favourably
Roald A Lambrechts et al.
EMBO molecular medicine, 11(12), e10488-e10488 (2019-11-09)
PKAN, CoPAN, MePAN, and PDH-E2 deficiency share key phenotypic features but harbor defects in distinct metabolic processes. Selective damage to the globus pallidus occurs in these genetic neurodegenerative diseases, which arise from defects in CoA biosynthesis (PKAN, CoPAN), protein lipoylation
Yongchong Yang et al.
European journal of medicinal chemistry, 45(9), 4300-4306 (2010-07-29)
A current study shows that sodium dichloroacetate (DCA) can induce cancer cell apoptosis and inhibit tumor growth, but its cytotoxic activity is low (IC(50) > 1000 microM for A549). In this paper, a variety of DCA derivatives were synthesized, and
Han Shen et al.
Molecular cancer therapeutics, 14(8), 1794-1804 (2015-06-13)
Because radiotherapy significantly increases median survival in patients with glioblastoma, the modulation of radiation resistance is of significant interest. High glycolytic states of tumor cells are known to correlate strongly with radioresistance; thus, the concept of metabolic targeting needs to
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