Reduced renal sympathetic nerve activity contributes to elevated glycosuria and improved glucose tolerance in hypothalamus-specific Pomc knockout mice.

Hypothalamic arcuate nucleus-specific pro-opiomelanocortin deficient (ArcPomc We measured RSNA by multifiber recording directly from the nerves innervating the kidneys in ArcPomc Consistent with our hypothesis, we found that basal RSNA was decreased in ArcPomc Hence, we conclude that ArcPomc is essential in maintaining basal RSNA and that elevated glycosuria is a possible mechanism to explain improved glucose tolerance after renal denervation in drug resistant hypertensive patients.