- Synthesis and Characterization of Novel Acyl-Glycine Inhibitors of GlyT2.
Synthesis and Characterization of Novel Acyl-Glycine Inhibitors of GlyT2.
ACS chemical neuroscience (2017-06-03)
Shannon N Mostyn, Jane E Carland, Susan Shimmon, Renae M Ryan, Tristan Rawling, Robert J Vandenberg
PMID28574249
RÉSUMÉ
It has been demonstrated previously that the endogenous compound N-arachidonyl-glycine inhibits the glycine transporter GlyT2, stimulates glycinergic neurotransmission, and provides analgesia in animal models of neuropathic and inflammatory pain. However, it is a relatively weak inhibitor with an IC
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