- Synthesis, characterization, and pharmacological evaluation of novel azolo- and azinothiazinones containing 2,4-dihydroxyphenyl substituent as anticancer agents.
Synthesis, characterization, and pharmacological evaluation of novel azolo- and azinothiazinones containing 2,4-dihydroxyphenyl substituent as anticancer agents.
Monatshefte fur chemie (2015-07-21)
Joanna Matysiak, Małgorzata Juszczak, Monika M Karpińska, Ewa Langner, Katarzyna Walczak, Marta Lemieszek, Alicja Skrzypek, Wojciech Rzeski, Andrzej Niewiadomy
PMID26190864
RÉSUMÉ
We reported the synthesis and characterization of a series of azolo- and azino[1,3]thiazinones containing the 2,4-dihydroxyphenyl substituent. The compounds were prepared by a new one-step reaction of aryl-modified sulfinylbis[(2,4-dihydroxyphenyl)methanethione]s and the corresponding aminoazolo(azino)carboxamides. Their chemical structures were confirmed by IR, NMR:
MATÉRIAUX
Référence du produit
Marque
Description du produit
Sigma-Aldrich
Sulfoxyde de diméthyle-d6, Diméthylsulfoxyde-d6, 99.9 atom % D, contains 0.03 % (v/v) TMS
Sigma-Aldrich
Sulfoxyde de diméthyle-d6, Diméthylsulfoxyde-d6, 99.9 atom % D, contains 1 % (v/v) TMS
Sigma-Aldrich
Sulfoxyde de diméthyle-d6, Diméthylsulfoxyde-d6, "100%", 99.96 atom % D, contains 0.03 % (v/v) TMS
Sigma-Aldrich
Methanol solution, NMR reference standard, 4% in methanol-d4 (99.8 atom % D), NMR tube size 3 mm × 8 in.