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Merck

Green procedure for the preparation of scented alcohols from carbonyl compounds.

International journal of cosmetic science (2008-04-02)
Carla Villa, Beatrice Trucchi, Raffaella Gambaro, Sara Baldassari
RÉSUMÉ

Several alcohols--interesting as cosmetic fragrances whose main preparative route on an industrial scale or in the research laboratory is the reduction of the corresponding carbonyl compound--were obtained by a solvent-free methodology in a green chemistry context. The process involves the simple mixing of the carbonyl compound with sodium borohydride dispersed in wet alumina in the solid state; the conversions of the carbonyl compounds were obtained in good yields within short reaction times, without energy consumption. The following carbinols were studied: octan-3-ol, 2-cineolylols (endo-exo mixture), alpha-ionol, 4-methylbenzyl alcohol, 1-phenylethanol, trans-cinnamyl alcohol, p-anisyl alcohol, 4-phenyl-3-buten-2-ol.

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Sigma-Aldrich
4-Methylbenzyl alcohol, 98%