- Design and synthesis of 8-substituted benzamido-phenylxanthine derivatives as MAO-B inhibitors.
Design and synthesis of 8-substituted benzamido-phenylxanthine derivatives as MAO-B inhibitors.
Bioorganic & medicinal chemistry letters (2012-01-20)
Bo Song, Tong Xiao, Xiaolu Qi, Ling-Na Li, Kuiyou Qin, Siyun Nian, Guo-Xin Hu, Yinfei Yu, Guang Liang, Faqing Ye
PMID22257893
RÉSUMÉ
Monoamine oxidase-B (MAO-B) inhibitor has been used as neuroprotectants to treat the motor deficits of Parkinson's disease (PD). We designed and synthesized a class of 8-substituted benzamido-phenylxanthine derivatives as MAO-B inhibitors. The compounds have various inhibitory effects, with compound 6a having a K(i) value of 0.26 μM. Their promising activity in vitro suggests potential use in the treatment of PD.
MATÉRIAUX