- Effect of common NAT2 variant alleles in the acetylation of the major clonazepam metabolite, 7-aminoclonazepam.
Effect of common NAT2 variant alleles in the acetylation of the major clonazepam metabolite, 7-aminoclonazepam.
Drug metabolism letters (2007-01-01)
M Olivera, C Martínez, G Gervasini, J A Carrillo, S Ramos, J Benítez, E García-Martin, J A G Agúndez
PMID19356010
RÉSUMÉ
We investigated the role of NAT2 on clonazepam acetylation, using transiently expressed human NAT2 alleles. The NAT25*B and the NAT2*6A variant alleles cause a 20 and 22-fold reduction in the Vmax, respectively. We conclude that NAT2 is responsible for 7-aminoclonazepam acetylation and that NAT2 gene polymorphisms impair such metabolic pathway.
MATÉRIAUX