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[Oxidised dextrans influence on reactive oxygen species generation by murine peritoneal exudate phagocytic cells].

Biomeditsinskaia khimiia (2013-05-09)
V O Tkachev, M V Zaĭkovskaia, A V Troitskiĭ, N G Luzgina, V A Shkurupiĭ
PMID23650725
RÉSUMÉ

The effects of oxidized dextrans of different molecular weight on reactive oxygen species production and transmembrane mitochondrial potential of macrophages and neutrophils have been studied in vivo and in vitro. Oxidised dextrans demonstrated moderate direct antioxidant ability but induced intracellular oxidative stress through the increase of oxygen radical generation. This effect of the investigated compounds amplifies the cytotoxic and bactericidal potential of phagocytes and can influence isoniazid metabolism, thus increasing its efficiency in therapy of infectious diseases.

MATÉRIAUX
Référence du produit
Marque
Description du produit
31392
Sigma-Aldrich
Dextrane from Leuconostoc spp., Mr 450,000-650,000
31390
Sigma-Aldrich
Dextrane from Leuconostoc spp., Mr ~70,000
31389
Sigma-Aldrich
Dextrane from Leuconostoc spp., Mr ~40,000
D9260
Sigma-Aldrich
Dextrane from Leuconostoc mesenteroides, average mol wt 9,000-11,000
D5376
Sigma-Aldrich
Dextrane from Leuconostoc mesenteroides, average mol wt 1,500,000-2,800,000
D8821
Sigma-Aldrich
Dextrane from Leuconostoc mesenteroides, average mol wt 60,000-76,000
D1662
Sigma-Aldrich
Dextrane from Leuconostoc mesenteroides, average mol wt 35,000-45,000
31388
Sigma-Aldrich
Dextrane from Leuconostoc spp., Mr ~6,000
00271
Supelco
Dextran, analytical standard, for GPC, 25,000
D4876
Sigma-Aldrich
Dextrane from Leuconostoc mesenteroides, average mol wt 150,000
09184
Sigma-Aldrich
Dextrane from Leuconostoc spp., Mr ~100,000
00269
Supelco
Dextran, analytical standard, for GPC, 5,000
I3377
Supelco
Isoniazid, analytical standard, ≥99% (TLC)
00268
Supelco
Dextran, analytical standard, for GPC, 1,000
31387
Sigma-Aldrich
Dextrane from Leuconostoc spp., Mr 15,000-25,000
31398
Sigma-Aldrich
Dextrane from Leuconostoc mesenteroides, Mr ~200,000
31397
Sigma-Aldrich
Dextrane from Leuconostoc mesenteroides, Mr ~60,000
31394
Sigma-Aldrich
Dextran, enzymatic synth.
D8802
Sigma-Aldrich
Dextran solution from Leuconostoc mesenteroides, 20 % (w/w) (Autoclaved)
31425
Supelco
Dextrane from Leuconostoc mesenteroides, analytical standard, for GPC, Mw 670,000
00894
Supelco
Dextran, analytical standard, for GPC, 270,000
D3759
Sigma-Aldrich
Dextrane from Leuconostoc mesenteroides, average mol wt 48,000-90,000
31417
Supelco
Dextrane from Leuconostoc mesenteroides, analytical standard, for GPC, Mw 5,000
D4626
Sigma-Aldrich
Dextrane from Leuconostoc mesenteroides, average mol wt 15,000-30,000
31416
Supelco
Dextrane from Leuconostoc mesenteroides, analytical standard, for GPC, Mw 1,000
31419
Supelco
Dextrane from Leuconostoc mesenteroides, analytical standard, for GPC, Mw 25,000
31430
Supelco
Dextran, analytical standard, for GPC, Set Mp 1,000-400,000
00891
Supelco
Dextran, analytical standard, for GPC, 50,000
00895
Supelco
Dextran, analytical standard, for GPC, 410,000
00892
Supelco
Dextran, analytical standard, for GPC, 80,000