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A flow cytometry-based dopamine transporter binding assay using antagonist-conjugated quantum dots.

Chemical communications (Cambridge, England) (2012-05-01)
Oleg Kovtun, Emily J Ross, Ian D Tomlinson, Sandra J Rosenthal
RÉSUMÉ

Here we present the development and validation of a flow cytometry-based dopamine transporter (DAT) binding assay that uses antagonist-conjugated quantum dots (QDs). We anticipate that our QD-based assay is of immediate value to the high throughput screening of novel DAT modulators.

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GBR 12909 dihydrochloride, solid, ≥98% (HPLC)