- Anti-mycobacterial activity of a bis-sulfonamide.
Anti-mycobacterial activity of a bis-sulfonamide.
Bioorganic & medicinal chemistry letters (2007-01-30)
Brendan L Wilkinson, Laurent F Bornaghi, Anthony D Wright, Todd A Houston, Sally-Ann Poulsen
PMID17258454
RÉSUMÉ
A bis-arylsulfonamide, 7, has been identified that exhibits growth inhibition of Mycobacterium smegmatis at less than 25 microg/mL, but has no such activity against Escherichia coli or Staphylococcus aureus. A closely related bis-arylsulfonamide (8) was much less active, but was the only other compound among 54 arylsulfonamides tested with detectable growth inhibition of M. smegmatis.
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