- Design and synthesis of a new class of malonyl-CoA decarboxylase inhibitors with anti-obesity and anti-diabetic activities.
Design and synthesis of a new class of malonyl-CoA decarboxylase inhibitors with anti-obesity and anti-diabetic activities.
Bioorganic & medicinal chemistry letters (2010-09-14)
Haifeng Tang, Yan Yan, Zhe Feng, Reynalda K de Jesus, Lihu Yang, Dorothy A Levorse, Karen A Owens, Taro E Akiyama, Raynald Bergeron, Gino A Castriota, Thomas W Doebber, Kenneth P Ellsworth, Michael E Lassman, Cai Li, Margaret S Wu, Bei B Zhang, Kevin T Chapman, Sander G Mills, Joel P Berger, Alexander Pasternak
PMID20832306
RÉSUMÉ
A new series of thiazole-substituted 1,1,1,3,3,3-hexafluoro-2-propanols were prepared and evaluated as malonyl-CoA decarboxylase (MCD) inhibitors. Key analogs caused dose-dependent decreases in food intake and body weight in obese mice. Acute treatment with these compounds also led to a drop in elevated blood glucose in a murine model of type II diabetes.