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SRP5215

SMYD3, GST tagged human

Name: SMYD3, GST tagged human
Brand: SIGMA

recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

Synonyme(s) :

FLJ21080, ZMYND1, ZNFN3A1

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About This Item

Code UNSPSC :

12352200

Nomenclature NACRES :

NA.32

Produit recombinant

expressed in baculovirus infected Sf9 cells

Pureté

≥70% (SDS-PAGE)

Forme

buffered aqueous glycerol solution

Poids mol.

~71 kDa

Numéro d'accès NCBI

BC031010

Conditions d'expédition

dry ice

Température de stockage

−70°C

Informations sur le gène

human ... SMYD3(64754)

Description générale

SMYD3 (SET and MYND domain containing 3) is a histone methyltransferase that plays a role in transcriptional regulation as a member of an RNA polymerase complex. The introduction of SMYD3 enhanced cell growth and the histone methyltransferase activity of SMYD3 involved in the proliferation of cancer cells. A variable number of tandems repeat polymorphism in an E2F-1 binding element in the 5-prime flanking region of SMYD3 is a risk factor for human cancers.

Forme physique

Supplied in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.

Notes préparatoires

after opening, aliquot into smaller quantities and store at -70 °C. Avoid repeating handling and multiple freeze/thaw cycles

Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

WGK 1

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

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A variable number of tandem repeats polymorphism in an E2F-1 binding element in the 5' flanking region of SMYD3 is a risk factor for human cancers.

Masataka Tsuge et al.

Nature genetics, 37(10), 1104-1107 (2005-09-13)

Histone modification is a crucial step in transcriptional regulation, and deregulation of the modification process is important in human carcinogenesis. We previously reported that upregulation of SMYD3, a histone methyltransferase, promoted cell growth in human colorectal and hepatocellular carcinomas. Here

SMYD3 encodes a histone methyltransferase involved in the proliferation of cancer cells.

Ryuji Hamamoto et al.

Nature cell biology, 6(8), 731-740 (2004-07-06)

Colorectal and hepatocellular carcinomas are some of the leading causes of cancer deaths worldwide, but the mechanisms that underly these malignancies are not fully understood. Here we report the identification of SMYD3, a gene that is over-expressed in the majority

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