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PRS3969

Sigma-Aldrich

Anti-Sumo antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

Synonyme(s) :

Anti-GAP-modifying protein 1, Anti-SMT3 suppressor of mif two 3 homolog 1 (S. cerevisiae), Anti-Ubiquitin-like protein 1, Anti-small-ubiquitin-like modifier 1

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About This Item

Numéro MDL:
Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41

Source biologique

rabbit

Conjugué

unconjugated

Forme d'anticorps

affinity isolated antibody

Type de produit anticorps

primary antibodies

Clone

polyclonal

Forme

buffered aqueous solution

Espèces réactives

mouse, human, rat

Technique(s)

immunofluorescence: suitable
immunohistochemistry: suitable
indirect ELISA: suitable
western blot: suitable

Numéro d'accès UniProt

Conditions d'expédition

dry ice

Température de stockage

−20°C

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

human ... SUMO1(7341)

Description générale

SUMO1 (small ubiquitin-related modifier) is also called as Pic1 (inner centromere protein-related protein), Ubl1 (ubiquitin-like protein), hSmt3 (human homolog 3), or sentrin. It is located in the nucleus. It is located in chromosome 2q33.
SUMO1 (small ubiquitin-related modifier) is also called as Pic1 (inner centromere protein-related protein), Ubl1 (ubiquitin-like protein), hSmt3 (human homolog 3), or sentrin. It is located in the nucleus. SUMO1 gene is located on human chromosome 2q33.

Immunogène

a 14 amino acid peptide from near the amino-terminus of human sumo.

Actions biochimiques/physiologiques

Suppressing SUMO1 (small ubiquitin-related modifier) stops multiplication and induces apoptosis of gastric cancer SGC-7901 cells. It is essential for HCV (hepatitis C virus) replication. Deletion of SUMO1 blocks the aggregation of lipid droplets. It involves in mitochondrial fission.
Suppressing SUMO1 (small ubiquitin-related modifier) stops multiplication and induces apoptosis of gastric cancer SGC-7901 cells. It is essential for HCV (hepatitis C virus) replication. Deletion of SUMO1 blocks the aggregation of lipid droplets. It is involved in mitochondrial fission.

Liaison

The action of this antibody can be blocked using blocking peptide SBP3969.

Forme physique

Solution in phosphate buffered saline containing 0.02% sodium azide

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Produit(s) apparenté(s)

Réf. du produit
Description
Tarif

Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

WGK 2

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable


Certificats d'analyse (COA)

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Consulter la Bibliothèque de documents

SUMO1 depletion prevents lipid droplet accumulation and HCV replication
Akil A, et al.
Archives of Virology, 161(1), 141-148 (2016)
The genetic basis of cleft lip and cleft palate
Veros C, et al.
Aristotle University Medical Journal, 43 (2016)
Sumo1 conjugates mitochondrial substrates and participates in mitochondrial fission
Harder Z, et al.
Current Biology, 14(4), 340-345 (2004)
The nucleoporin RanBP2 has SUMO1 E3 ligase activity
Pichler A, et al.
Cell, 108(1), 109-120 (2002)
SUMO-1 Gene Silencing Inhibits Proliferation and Promotes Apoptosis of Human Gastric Cancer SGC-7901 Cells
Jin L, et al.
Cellular Physiology and Biochemistry, 41(3), 987-998 (2017)

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