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Documents

I8280

Sigma-Aldrich

Indomethacin

meets USP testing specifications

Synonyme(s) :

1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-3-indoleacetic acid

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About This Item

Formule empirique (notation de Hill):
C19H16ClNO4
Numéro CAS:
53-86-1
Poids moléculaire :
357.79
Numéro Beilstein :
497341
Numéro CE :
200-186-5
Numéro MDL:
MFCD00057095
Code UNSPSC :
12352101
ID de substance PubChem :
24896136
Nomenclature NACRES :
NA.21

Agence

USP/NF
meets USP testing specifications

Pureté

98.0-102.0%

Forme

powder

Mode d’action

enzyme | inhibits

Chaîne SMILES 

COc1ccc2n(c(C)c(CC(O)=O)c2c1)C(=O)c3ccc(Cl)cc3

InChI

1S/C19H16ClNO4/c1-11-15(10-18(22)23)16-9-14(25-2)7-8-17(16)21(11)19(24)12-3-5-13(20)6-4-12/h3-9H,10H2,1-2H3,(H,22,23)

Clé InChI

CGIGDMFJXJATDK-UHFFFAOYSA-N

Informations sur le gène

human ... ALB(213) , ALOX5(240) , ELA2(1991) , GPR44(11251) , IL1A(3552) , PLA2G1B(5319) , PTGDR(5729) , PTGS1(5742) , PTGS2(5743)
mouse ... Alox5(11689) , Ptgdr(19214) , Ptger1(19216) , Ptger2(19217) , Ptger3(19218) , Ptger4(19219) , Ptgs1(19224) , Ptgs2(19225)
rat ... Alox5(25290) , Ptgs1(24693) , Ptgs2(29527)

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Actions biochimiques/physiologiques

Cyclooxygenase (COX) inhibitor that is relatively selective for COX-1.
Used as a non-selective inhibitor of cyclooxygenases, COX1 and COX2, leading to reduced prostaglandin biosynthesis from arachidonic acid.

Pictogrammes

Skull and crossbones
GHS06

Mention d'avertissement

Danger

Mentions de danger

H300

Conseils de prudence

P264 - P301 + P310

Classification des risques

Acute Tox. 1 Oral

Code de la classe de stockage

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Indomethacin Related Compound A United States Pharmacopeia (USP) Reference Standard

USP

1417113

Indomethacin Related Compound A

Atosiban ≥98% (HPLC)

Sigma-Aldrich

A3480

Atosiban

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Sigma-Aldrich

I2643

Insuline human

Dexaméthasone meets USP testing specifications

Sigma-Aldrich

D9184

Dexaméthasone

Rosiglitazone ≥98% (HPLC)

Sigma-Aldrich

R2408

Rosiglitazone

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Journal of medicinal chemistry, 54(5), 1356-1364 (2011-02-02)
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We determined the intrinsic aqueous solubility of 15 poorly soluble drugs with solubilities ranging from 2.9 nM to 1.1 microM. We then analyzed the data from a physicochemical perspective, using experimentally determined solid-state properties and easily interpretable two-dimensional molecular descriptors
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