229A-1

Calcitonin Rabbit Polyclonal Antibody

• Code UNSPSC : 12352203
• Nomenclature NACRES : NA.41

Propriétés

• Source biologique: rabbit
• Niveau de qualité: 100; 500
• Conjugué: unconjugated
• Forme d'anticorps: Ig fraction of antiserum
• Type de produit anticorps: primary antibodies
• Clone: polyclonal
• Description: For In Vitro Diagnostic Use in Select Regions (See Chart)
• Forme: buffered aqueous solution
• Espèces réactives: human
• Conditionnement: vial of 0.1 mL concentrate (229A-14); vial of 0.5 mL concentrate (229A-15); bottle of 1.0 mL predilute (229A-17); vial of 1.0 mL concentrate (229A-16); bottle of 7.0 mL predilute (229A-18)
• Fabricant/nom de marque: Cell Marque^™
• Technique(s): immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:200-1:1000
• Contrôle: medullary carcinoma of thyroid
• Conditions d'expédition: wet ice
• Température de stockage: 2-8°C
• Visualisation: cytoplasmic

Description

Description générale

Calcitonin (thyrocalcitonin) is a 32 amino acid linear polypeptide hormone that is involved in regulating calcium metabolism. It is primarily produced by the parafollicular cells (also known as C cells) of the thyroid gland, though some neuroendocrine cells in other tissues, such as the respiratory and digestive tracts, can also synthesize calcitonin. Anti-calcitonin immunohistochemistry is an effective way for demonstrating the parafollicular C cells in the thyroid and the tumors arising from them, including C cell hyperplasia of the thyroid and medullary thyroid carcinoma, a neuroendocrine tumor that originates from C cells.
Immunohistochemical staining with anti-calcitonin antibodies has proven to be an effective way of demonstrating calcitonin-producing cells in the thyroid. C-cell hyperplasia and medullary thyroid carcinomas stain positive for calcitonin. Studies of calcitonin have resulted in the identification of a wide spectrum of C-cell proliferative abnormalities.

Liaison

Calcitonin Positive Control Slides, Product No. 229S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Forme physique

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

Notes préparatoires

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Autres remarques

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Informations légales

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany