MABS409
Anti-NFATc1 Antibody, clone 7A6
clone 7A6, from mouse
Synonyme(s) :
Nuclear factor of activated T-cells, cytoplasmic 1, NF-ATc1, NFATc1, NFAT transcription complex cytosolic component, NF-Atc, NFATc
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About This Item
Code UNSPSC :
12352203
eCl@ss :
32160702
Nomenclature NACRES :
NA.41
Produits recommandés
Source biologique
mouse
Forme d'anticorps
purified immunoglobulin
Type de produit anticorps
primary antibodies
Clone
7A6, monoclonal
Espèces réactives
human, mouse
Technique(s)
flow cytometry: suitable
immunofluorescence: suitable
western blot: suitable
Isotype
IgG1
Numéro d'accès UniProt
Conditions d'expédition
wet ice
Modification post-traductionnelle de la cible
unmodified
Informations sur le gène
human ... NFATC1(4772)
Description générale
NFATc1, also known as Nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1, is a component of the nuclear factor of activated T cells DNA-binding transcription complex which consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation, and an inducible nuclear component. This protein plays a main role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 or IL-4 gene transcription and functions as a major molecular target for the immunosuppressive drugs such as cyclosporine A. NFATc1 is expressed in most human primary lymphocytes and mature human T- and B-cell neoplasms.
Immunogène
Recombinant protein of human NFATc1 amino acids 197-304
Application
Detect NFAT using this mouse monoclonal antibody, Anti-NFATc1 Antibody, clone 7A6 validated for use in western blotting, Flow Cytometry & Immunofluorescence.
Flow Cytometry Analysis: A representative lot detected human NFATc1 in Flow Cytometry. (Brandt C, et al. 2010.)
Immunofluorescent Analysis: A representative lot detected human NFATc1 in Immunofluorescence. (Timmerman LA, et al. 1997.)
Immunofluorescent Analysis: A representative lot detected human NFATc1 in Immunofluorescence. (Timmerman LA, et al. 1997.)
Qualité
Evaluated by Western Blotting in Jurkat, human Th1, and mouse Th1 cell extracts.
Western Blotting Analysis: 1 μg/mL of this antibody detected in Jurkat, human Th1, and mouse Th1 cell extracts.
Western Blotting Analysis: 1 μg/mL of this antibody detected in Jurkat, human Th1, and mouse Th1 cell extracts.
Description de la cible
~~95, ~110 and ~130 kDa observed
Forme physique
Format: Purified
Purified mouse monoclonal IgG1 antibody in buffer containing PBS (pH 7.2) with up to 0.1% sodium azide.
Stockage et stabilité
The antibody solution should be stored undiluted at 2-8°C and protected from prolonged exposure to light. Do not freeze.
Autres remarques
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
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Code de la classe de stockage
12 - Non Combustible Liquids
Classe de danger pour l'eau (WGK)
WGK 2
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
Certificats d'analyse (COA)
Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".
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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.
Krithika Ramachandran et al.
PLoS biology, 17(10), e3000467-e3000467 (2019-10-08)
Skeletal muscles consist of fibers of differing metabolic activities and contractility, which become remodeled in response to chronic exercise, but the epigenomic basis for muscle identity and adaptation remains poorly understood. Here, we used chromatin immunoprecipitation sequencing of dimethylated histone
Celestia Fang et al.
Journal of immunology (Baltimore, Md. : 1950), 196(11), 4452-4456 (2016-05-18)
Osteoclasts are resorptive cells that are important for homeostatic bone remodeling and pathological bone resorption. Emerging evidence suggests an important role for epigenetic mechanisms in osteoclastogenesis. A recent study showed that epigenetic silencing of the negative regulator of osteoclastogenesis Irf8
Novel Bruton's tyrosine kinase inhibitor TAS5315 suppresses the progression of inflammation and joint destruction in rodent collagen-induced arthritis.
Akasaka, et al.
PLoS ONE, 18, e0282117-e0282117 (2023)
Shi-Ying Cai et al.
Journal of hepatology, 74(3), 550-559 (2020-10-12)
The nuclear factor of activated T-cells (NFAT) plays an important role in immune responses by regulating the expression of inflammatory genes. However, it is not known whether NFAT plays any role in the bile acid (BA)-induced hepatic inflammatory response. Thus
Amado Carreras-Sureda et al.
eLife, 10 (2021-12-17)
Efficient immune responses require Ca2+ fluxes across ORAI1 channels during engagement of T cell receptors (TCR) at the immune synapse (IS) between T cells and antigen presenting cells. Here, we show that ZDHHC20-mediated S-acylation of the ORAI1 channel at residue
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