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407952

Sigma-Aldrich

Ionomycin, Calcium Salt, Streptomyces conglobatus

Ionomycin, Calcium Salt, Streptomyces conglobatus, CAS 56092-82-1, is useful in cell activation experiments when calcium dose-response data are not required.

Synonyme(s) :

Ionomycin, Calcium Salt, Streptomyces conglobatus

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About This Item

Formule empirique (notation de Hill):
C41H70O9 · Ca
Numéro CAS:
56092-82-1
Poids moléculaire :
747.07
Numéro MDL:
MFCD00083634
Code UNSPSC :
12352200

Niveau de qualité

100

Pureté

≥97% (HPLC)

Forme

solid

Fabricant/nom de marque

Calbiochem®

Conditions de stockage

OK to freeze
protect from light

Couleur

white to off-white

Solubilité

DMSO: 100 mg/mL

Conditions d'expédition

ambient

Température de stockage

2-8°C

InChI

1S/C41H71O9.Ca/c1-25(21-29(5)34(43)24-35(44)30(6)22-27(3)20-26(2)14-15-38(46)47)12-11-13-28(4)39(48)31(7)36(45)23-33-16-18-41(10,49-33)37-17-19-40(9,50-37)32(8)42;/h11,13,24-33,36-37,39,42,45,48H,12,14-23H2,1-10H3,(H,46,47);/q-1;+2/p-1/b13-11+;/t25-,26-,27+,28-,29-,30+,31+,32-,33+,36+,37-,39-,40+,41+;/m1./s1

Clé InChI

RULWQOBWZOQCOY-SQNLDGQHSA-M

Description générale

Highly specific for divalent cations (Ca2+ > Mg2+ >> Sr2+ = Ba2+) and more effective than antibiotic A23187 (Cat. No. 100105) as a mobile ion carrier for Ca2+. Complexes with Ca2+ between pH 7 and 9.5, with intense UV absorption. In contrast to A23187, it is not fluorescent. Useful for studies of Ca2+ transport across biological membranes. Induces apoptotic neuronal degeneration in embryonic cortical neurons. Also induces cell cycle arrest in the G1 interval of mature Burkitt lymphoma cell lines. Often used in cell activation experiments when calcium dose-response data is not required.
Useful in cell activation experiments when calcium dose-response data are not required. Also available as a 10 mM solution in DMSO (Cat. No. 407953).

Actions biochimiques/physiologiques

Cell permeable: no
Primary Target
Useful in cell activation experiments
Product does not compete with ATP.
Reversible: no

Conditionnement

Packaged under inert gas

Avertissement

Toxicity: Harmful (C)

Autres remarques

Dupuy d′Angeac, A., et al. 1993. J. Cell Physiol.154, 44.
Lee, H.C. 1993. J. Biol. Chem.268, 293.

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Pictogrammes

Exclamation mark
GHS07

Mention d'avertissement

Warning

Mentions de danger

H302

Classification des risques

Acute Tox. 4 Oral

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

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Consulter la Bibliothèque de documents

Alfredo J Hernandez et al.
Proceedings of the National Academy of Sciences of the United States of America, 117(1), 415-425 (2019-12-25)
Transposable elements make up half of the mammalian genome. One of the most abundant is the short interspersed nuclear element (SINE). Among their million copies, B2 accounts for ∼350,000 in the mouse genome and has garnered special interest because of
Diana P Saraiva et al.
Frontiers in oncology, 10, 1543-1543 (2020-09-26)
3D cell culture including different cell types, such as immune cells, is a representative platform that mimics the tumor microenvironment. Here we disclose an easy-to-handle 3D co-culture protocol using a scaffold-free technique with the breast cancer cell line MDA-MB-231 and
Jinfeng Cai et al.
eLife, 10 (2021-04-10)
The major barrier to curing HIV-1 infection is a small pool of latently infected cells that harbor replication-competent viruses, which are widely considered the origin of viral rebound when antiretroviral therapy (ART) is interrupted. The difficulty in distinguishing latently infected cells
Yojet Sharma et al.
Wellcome open research, 5, 16-16 (2020-03-21)
The development of the human brain involves multiple cellular processes including cell division, migration, and dendritic growth. These processes are triggered by developmental cues and lead to interactions of neurons and glial cells to derive the final complex organization of
Aline M Thomas et al.
Journal of cellular physiology, 235(6), 5120-5129 (2019-11-02)
Dendritic cells are key players in regulating immunity. These cells both activate and inhibit the immune response depending on their cellular environment. Their response to hyperglycemia, a condition common amongst diabetics wherein glucose is abnormally elevated, remains to be elucidated.
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