377980

Hispidin

A potent, cell permeable, and reversible inhibitor of protein kinase Cβ isoform (PKCβ; IC₅₀ = 2 µM).

• Synonyme(s) : Hispidin, 6-(3,4-Dihydroxystyrl)-4-hydroxy-2-pyrone
• Formule empirique (notation de Hill): C₁₃H₁₀O₅
• Numéro CAS: 555-55-5
• Poids moléculaire : 246.22
• Numéro MDL: MFCD01866972
• Code UNSPSC : 12352200

Propriétés

• Niveau de qualité: 100
• Essai: ≥90% (HPLC)
• Forme: powder
• Fabricant/nom de marque: Calbiochem^®
• Conditions de stockage: OK to freeze; protect from light
• Couleur: yellow
• Solubilité: DMSO: 5 mg/mL
• Conditions d'expédition: ambient
• Température de stockage: −20°C
• InChI: 1S/C13H10O5/c14-9-6-10(18-13(17)7-9)3-1-8-2-4-11(15)12(16)5-8/h1-7,15-17H/b3-1+
• Clé InChI: QISBNGLMCHHHFG-HNQUOIGGSA-N

Description

Description générale

A potent, cell permeable, and reversible inhibitor of protein kinase Cβ isoform (PKC_β; IC₅₀ = 2 µM). Has stronger cytotoxic effects on cancer cells than on normal cells in vitro.

A potent, cell permeable, and reversible inhibitor of protein kinase C_β isoform (PKC_β; IC₅₀ = 2 µM). Has stronger cytotoxic effects on cancer cells than on normal cells in vitro.

Actions biochimiques/physiologiques

Cell permeable: yes

Primary Target
PKCβ

Product does not compete with ATP.

Reversible: yes

Target IC₅₀: 2 µM against PKCβ

Conditionnement

Packaged under inert gas

Avertissement

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Autres remarques

Gonindard, C., et al. 1997. Cell Biol. Toxicol. 13, 141.

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): No data available
• Point d'éclair (°C): No data available