07-218
Anti-Notch1 Antibody, extracellular domain
Upstate®, from rabbit
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About This Item
Code UNSPSC :
12352203
eCl@ss :
32160702
Source biologique
rabbit
Niveau de qualité
Type de produit anticorps
primary antibodies
Clone
polyclonal
Espèces réactives
rat, mouse
Fabricant/nom de marque
Upstate®
Technique(s)
western blot: suitable
Isotype
IgG
Numéro d'accès NCBI
Numéro d'accès UniProt
Conditions d'expédition
wet ice
Informations sur le gène
human ... NOTCH1(4851)
Description générale
The Notch protein family is a group of highly conserved proteins important in the determination of cell fate and maintenance of progenitors in many developmental systems. This family of proteins function both as membrane cell receptors and as transcription factors. Activation of Notch by cell-cell interactions causes a transcription inhibitory effect that enables inhibition of differentiation in some cells but not in others. As a consequence, some cells adopt a particular fate while other progenitors remain uncommitted. The Notch protein is important in cell fate during myogenesis, neurogenesis, oogenesis, and wing and eye development in Drosophila. In mammals, four Notch genes were identified (Notch 1-4) that are expressed in a wide variety of cells and play a crucial role in differentiation and development.
Spécificité
Notch1
Immunogène
N-terminal GST fusion protein corresponding to residues 381-853 of rat Notch1
Application
Anti-Notch1 Antibody, extracellular domain is a high quality Rabbit Polyclonal Antibody for the detection of Notch1 & has been validated in WB.
Research Category
Epigenetics & Nuclear Function
Epigenetics & Nuclear Function
Research Sub Category
Transcription Factors
Transcription Factors
Used in mouse in the following publication: Gulino, R., et al, European Journal of Neuroscience, Vol. 31, pp. 1423–1434, 2010.
Qualité
Routinely evaluated by immunoblot on RIPA lysates from L/N17 rat Notch1 transfected fibroblast cells
Description de la cible
260kDa
Liaison
Replaces: 04-1046
Forme physique
Format: Purified
Protein A chromatography
Protein A purified immunoglobulin presented in 0.1M Tris-Glycine, 0.15M NaCl, and 0.05% Sodium Azide, pH 7.4
Stockage et stabilité
Stable for 1 year at 2-8°C from date of receipt.
Remarque sur l'analyse
Control
L/N17 transfected Notch1 cell lysate
L/N17 transfected Notch1 cell lysate
Informations légales
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
Clause de non-responsabilité
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Code de la classe de stockage
10-13 - German Storage Class 10 to 13
Certificats d'analyse (COA)
Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".
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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.
NF-kappaB2 is a putative target gene of activated Notch-1 via RBP-Jkappa
Oswald, F, et al
Molecular and cellular biology, 18, 2077-2088 (1998)
C M Blaumueller et al.
Cell, 90(2), 281-291 (1997-07-25)
Previous models for signal transduction via the Notch pathway have depicted the full-length Notch receptor expressed at the cell surface. We present evidence demonstrating that the Notch receptor on the plasma membrane is cleaved. This cleavage is an evolutionarily conserved
G Struhl et al.
Cell, 93(4), 649-660 (1998-05-30)
The Drosophila Notch (N) gene encodes a conserved single-pass transmembrane receptor that transduces extracellular signals controlling cell fate. Here, we present evidence that the intracellular domain of Notch gains access to the nucleus in response to ligand, possibly through a
Notch signaling: direct or what?
Weinmaster, G
Current Opinion in Genetics & Development, 8, 436-442 (1998)
Bo Yan et al.
The Journal of biological chemistry, 277(33), 29760-29764 (2002-06-18)
Acid alpha-glucosidase (GAA) is a lysosomal enzyme that degrades glycogen. A deficiency of GAA is responsible for a recessively inherited myopathy and cardiomyopathy, glycogenosis type II. Previously, we identified an intronic repressor element in the GAA gene and demonstrated that
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