TOP2A
topoisomerase (DNA) II alpha 170kDa
Synonymes:
TOP2, TP2A
Espèce(s):
Human TOP2A (7153), Mouse Top2a (21973), Rat Top2a (360243), dog TOP2A (480525), Domestic Rabbit TOP2A (100357676), Zebrafish top2a (323733), chicken TOP2A (395570), sheep TOP2A (101108762), domestic guinea pig Top2a (100730168), cow TOP2A (787696)
ID UniProtKB:
ID du gène:
- Human(7153) Summary: This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, alpha, is localized to chromosome 17 and the beta gene is localized to chromosome 3. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia. [provided by RefSeq, Jul 2010]
- Mouse(21973) topoisomerase (DNA) II alpha
- Rat(360243) topoisomerase (DNA) II alpha
- dog(480525) topoisomerase (DNA) II alpha 170kDa
- Domestic Rabbit(100357676) topoisomerase (DNA) II alpha 170kDa
- Zebrafish(323733) topoisomerase (DNA) II alpha
- chicken(395570) topoisomerase (DNA) II alpha 170kDa
- sheep(101108762) topoisomerase (DNA) II alpha 170kDa
- domestic guinea pig(100730168) topoisomerase (DNA) II alpha 170kDa
- cow(787696) topoisomerase (DNA) II alpha 170kDa
- domestic cat(101083813) topoisomerase (DNA) II alpha 170kDa
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Antibodies
Référence du produit
Description
Espèces réactives
Application
Anti-Topoisomerase II Antibody, clone 3C3 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Espèces réactives
human, mouse
Application
affinity binding assay
immunocytochemistry
immunohistochemistry
western blot
immunocytochemistry
immunohistochemistry
western blot
Anti-TOP2A antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution, Ab1,
Espèces réactives
human
Application
immunohistochemistry
western blot
western blot
Anti-Topoisomerase II Antibody, clone KiS1, clone KiS1, Chemicon®, from mouse,
Espèces réactives
human
Application
flow cytometry
immunocytochemistry
immunohistochemistry
western blot
immunocytochemistry
immunohistochemistry
western blot
TOP2A (Topoisomerase IIα) Rabbit Monoclonal Antibody, clone RM394, affinity purified immunoglobulin,
Espèces réactives
human
Application
immunohistochemistry
western blot
western blot
Monoclonal Anti-TOP2A antibody produced in mouse, clone 1E2, purified immunoglobulin, buffered aqueous solution,
Espèces réactives
human
Application
ELISA
immunofluorescence
immunohistochemistry
western blot
immunofluorescence
immunohistochemistry
western blot
Small Molecule - Inhibitor
Référence du produit
Description
Espèce(s)
Doxorubicine hydrochloride, United States Pharmacopeia (USP) Reference Standard,
Espèce(s)
human
Proteins
Référence du produit
Description
Espèce(s)