SCN1A
sodium channel, voltage-gated, type I, alpha subunit
Synonymes:
EIEE6, FEB3, FEB3A, FHM3, GEFSP2, HBSCI, NAC1, Nav1.1, SCN1, SMEI
Espèce(s):
Human SCN1A (6323), Mouse Scn1a (20265), Rat Scn1a (81574), domestic guinea pig Scn1a (100715839), chicken SCN1A (771555), naked mole-rat Scn1a (101710495), Zebrafish scn1a (100536219), Zebrafish scn1a (393101), cow SCN1A (529590), dog SCN1A (478775) ...Plus
ID UniProtKB:
ID du gène:
- Human(6323) Summary: The vertebrate sodium channel is a voltage-gated ion channel essential for the generation and propagation of action potentials, mainly in nerve and muscle. Voltage-sensitive sodium channels are heteromeric complexes consisting of a large central pore-forming glycosylated alpha subunit, and two smaller auxiliary beta subunits. This gene encodes the large alpha subunit, and mutations in this gene have been associated with several epilepsy, convulsion and migraine disorders. Alternative splicing results in multiple transcript variants. The RefSeq Project has decided to create four representative RefSeq records. Three of the transcript variants are supported by experimental evidence and the fourth contains alternate 5' untranslated exons, the exact combination of which have not been experimentally confirmed for the full-length transcript.[provided by RefSeq, Jan 2011]
- Mouse(20265) sodium channel, voltage-gated, type I, alpha
- Rat(81574) sodium channel, voltage-gated, type I, alpha
- domestic guinea pig(100715839) sodium channel, voltage-gated, type I, alpha subunit
- chicken(771555) sodium channel, voltage-gated, type I, alpha subunit
- naked mole-rat(101710495) sodium channel, voltage-gated, type I, alpha subunit
- Zebrafish(100536219) sodium channel, voltage-gated, type I, alpha subunit
- Zebrafish(393101) sodium channel, voltage-gated, type I, alpha
- cow(529590) sodium channel, voltage-gated, type I, alpha subunit
- dog(478775) sodium channel, voltage-gated, type I, alpha subunit
- Horse(100052059) sodium channel, voltage-gated, type I, alpha subunit
- sheep(101123531) sodium channel, voltage-gated, type I, alpha subunit
- domestic cat(101081823) sodium channel, voltage-gated, type I, alpha subunit
- Domestic Rabbit(100009591) sodium channel, voltage-gated, type I, alpha subunit
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Small Molecule - Antagonist
Antibodies
Référence du produit
Description
Espèces réactives
Application
Anticorps anti-canaux sodiques voltage-dépendants, de type cérébral I, Chemicon®, from rabbit,
Espèces réactives
mouse, rat
Application
immunohistochemistry
western blot
western blot
Anti-Sodium Channel, Pan antibody produced in rabbit, affinity isolated antibody, lyophilized powder,
Espèces réactives
rat
Application
immunohistochemistry
immunoprecipitation (IP)
western blot
immunoprecipitation (IP)
western blot
Anticorps anti-canaux sodiques, voltage-dépendants, pan (segment SP19), Chemicon®, from rabbit,
Espèces réactives
mouse, rat
Application
immunohistochemistry
western blot
western blot
Anti-Sodium Channel, Brain Type I (α subunit) antibody produced in rabbit, affinity isolated antibody, lyophilized powder,
Espèces réactives
mouse, rat
Application
immunohistochemistry
western blot
western blot
Anticorps monoclonal anti-canal sodique, Pan antibody produced in mouse, ~1 mg/mL, clone K58/35, purified immunoglobulin,
Espèces réactives
mammals
Application
immunofluorescence
immunohistochemistry
western blot
immunohistochemistry
western blot
Small Molecule - Blocker
Référence du produit
Description
Espèce(s)
Lidocaine hydrochloride, Pharmaceutical Secondary Standard; Certified Reference Material,
Espèce(s)
human
Small Molecule - Inhibitor
Référence du produit
Description
Espèce(s)