Accéder au contenu
Merck

PSMC3

proteasome (prosome, macropain) 26S subunit, ATPase, 3

Synonymes:
TBP1
Espèce(s):
ID UniProtKB:
ID du gène:
  • Human(5702) Summary: The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases that have chaperone-like activity. This subunit may compete with PSMC2 for binding to the HIV tat protein to regulate the interaction between the viral protein and the transcription complex. A pseudogene has been identified on chromosome 9. [provided by RefSeq, Jul 2008]
  • Mouse(19182) proteasome (prosome, macropain) 26S subunit, ATPase 3
  • Rat(29677) proteasome (prosome, macropain) 26S subunit, ATPase 3
  • Zebrafish(321947) proteasome (prosome, macropain) 26S subunit, ATPase, 3
  • chicken(423182) proteasome (prosome, macropain) 26S subunit, ATPase, 3
  • domestic guinea pig(100727371) proteasome (prosome, macropain) 26S subunit, ATPase, 3
  • naked mole-rat(101706267) proteasome (prosome, macropain) 26S subunit, ATPase, 3
  • sheep(101117873) proteasome (prosome, macropain) 26S subunit, ATPase, 3
  • Domestic Rabbit(100354000) proteasome (prosome, macropain) 26S subunit, ATPase, 3
  • cow(508448) proteasome (prosome, macropain) 26S subunit, ATPase, 3
  • Horse(100051468) proteasome (prosome, macropain) 26S subunit, ATPase, 3
  • domestic cat(101095435) proteasome (prosome, macropain) 26S subunit, ATPase, 3
  • dog(475980) proteasome (prosome, macropain) 26S subunit, ATPase, 3

Custom & Knockdown Gene Products

  • siRNA

    Shop predesigned siRNA that are designed using the proprietary Rosetta Inpharmatics algorithm.

  • shRNA

    Shop the largest, most validated shRNA collection and build your own clone sets.

  • Custom Gene Products

    We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.

Antibodies

Référence du produit
Description
Espèces réactives
Application
Anti-PSMC3 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Espèces réactives
human, mouse, rat
Application
immunofluorescence
immunohistochemistry

western blot
Anti-PSMC3 antibody produced in mouse, purified immunoglobulin, buffered aqueous solution,
Espèces réactives
human, rat
Application
western blot
Monoclonal Anti-PSMC3 antibody produced in mouse, clone 1B9, purified immunoglobulin, buffered aqueous solution,
Espèces réactives
human
Application
ELISA
western blot
Anti-PRS6A antibody produced in rabbit, affinity isolated antibody,
Espèces réactives
human, mouse, rat
Application
ELISA
western blot
Anti-PSMC3 (ab1) antibody produced in rabbit, affinity isolated antibody,
Espèces réactives
bovine, dog, guinea pig, horse, human, mouse, rabbit, rat, yeast
Application
western blot

esiRNA

Référence du produit
Description
Espèce(s)
MISSION® esiRNA, targeting human PSMC3,
Espèce(s)
human
MISSION® esiRNA, targeting mouse Psmc3,
Espèce(s)
mouse