Accéder au contenu
Merck

POLR2A

polymerase (RNA) II (DNA directed) polypeptide A, 220kDa

Synonymes:
POLR2, POLRA, RPB1, RPBh1, RPO2, RPOL2, RpIILS, hRPB220, hsRPB1
Espèce(s):
ID UniProtKB:
ID du gène:
  • Human(5430) Summary: This gene encodes the largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. The product of this gene contains a carboxy terminal domain composed of heptapeptide repeats that are essential for polymerase activity. These repeats contain serine and threonine residues that are phosphorylated in actively transcribing RNA polymerase. In addition, this subunit, in combination with several other polymerase subunits, forms the DNA binding domain of the polymerase, a groove in which the DNA template is transcribed into RNA. [provided by RefSeq, Jul 2008]
  • Mouse(20020) polymerase (RNA) II (DNA directed) polypeptide A
  • Rat(363633) polymerase (RNA) II (DNA directed) polypeptide A
  • cow(282312) polymerase (RNA) II (DNA directed) polypeptide A, 220kDa
  • naked mole-rat(101725588) polymerase (RNA) II (DNA directed) polypeptide A, 220kDa
  • dog(479483) polymerase (RNA) II (DNA directed) polypeptide A, 220kDa
  • Zebrafish(553347) polymerase (RNA) II (DNA directed) polypeptide A
  • sheep(100144762) polymerase (RNA) II (DNA directed) polypeptide A, 220kDa
  • domestic cat(101098500) polymerase (RNA) II (DNA directed) polypeptide A, 220kDa
  • domestic guinea pig(100734232) polymerase (RNA) II (DNA directed) polypeptide A, 220kDa

Custom & Knockdown Gene Products

  • siRNA

    Shop predesigned siRNA that are designed using the proprietary Rosetta Inpharmatics algorithm.

  • shRNA

    Shop the largest, most validated shRNA collection and build your own clone sets.

  • Custom Gene Products

    We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.

Antibodies

Référence du produit
Description
Espèces réactives
Application
Anti-RNA Polymerase II Antibody, CTD Antibody, clone 8WG16, clone 8WG16, from mouse,
Espèces réactives
human, yeast
Application
dot blot
immunoprecipitation (IP)

inhibition assay

western blot
Anticorps anti-phospho ARN Pol II (Ser5), clone 1H4B6, clone 1H4B6, from rat,
Espèces réactives
canine, human, monkey, mouse, rat
Application
ChIP
ELISA

immunocytochemistry

western blot
Monoclonal Anti-phospho-RNA polymerase II CTD (pSer2) antibody produced in rat, clone 3E7C7, purified from hybridoma cell culture,
Espèces réactives
Application
flow cytometry
immunofluorescence

western blot
Anti-phospho RNA Pol II (Ser2), clone 3E7C7 Antibody, clone 3E7C7, from rat,
Espèces réactives
canine, human, monkey, mouse, rat
Application
ChIP
ELISA

immunocytochemistry

western blot
Anti-POLR2A antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
Espèces réactives
human
Application
immunofluorescence

Proteins

Référence du produit
Description
Espèce(s)
RNA Polymerase II, C-terminal domain, GST tagged human, recombinant, expressed in E. coli, ≥70% (SDS-PAGE),
Espèce(s)
human
RNA Polymerase II, C-terminal human, recombinant, expressed in E. coli, ≥85% (SDS-PAGE),
Espèce(s)
human

esiRNA

Référence du produit
Description
Espèce(s)
MISSION® esiRNA, targeting human POLR2A,
Espèce(s)
human
MISSION® esiRNA, targeting mouse Polr2a,
Espèce(s)
mouse