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Merck

PIK3R1

phosphoinositide-3-kinase, regulatory subunit 1 (alpha)

Synonymes:
AGM7, GRB1, p85, p85-ALPHA
Espèce(s):
Human PIK3R1 (5295), Mouse Pik3r1 (18708), Rat Pik3r1 (25513), domestic guinea pig Pik3r1 (100730242), domestic cat PIK3R1 (100271864), cow PIK3R1 (282307), sheep PIK3R1 (101121455), chicken PIK3R1 (427171), Zebrafish pik3r1 (557176), dog PIK3R1 (487235)
ID UniProtKB:
P27986, B3KT19, D3DWA0, E7EX19, Q15747, Q4VBZ7, Q53EM6, Q8IXA2
ID du gène:
  • Human(5295) Summary: Phosphatidylinositol 3-kinase phosphorylates the inositol ring of phosphatidylinositol at the 3-prime position. The enzyme comprises a 110 kD catalytic subunit and a regulatory subunit of either 85, 55, or 50 kD. This gene encodes the 85 kD regulatory subunit. Phosphatidylinositol 3-kinase plays an important role in the metabolic actions of insulin, and a mutation in this gene has been associated with insulin resistance. Alternative splicing of this gene results in four transcript variants encoding different isoforms. [provided by RefSeq, Jun 2011]
  • Mouse(18708) phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha)
  • Rat(25513) phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
  • domestic guinea pig(100730242) phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
  • domestic cat(100271864) phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
  • cow(282307) phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
  • sheep(101121455) phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
  • chicken(427171) phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
  • Zebrafish(557176) phosphoinositide-3-kinase, regulatory subunit 1 (p85 alpha)
  • dog(487235) phosphoinositide-3-kinase, regulatory subunit 1 (alpha)

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Antibodies

Référence du produit
Description
Espèces réactives
Application
05-212
Anticorps anti-PI3 kinase, p85, N-SH3, clone AB6, clone AB6, Upstate®, from mouse,
Espèces réactives
human, mouse, rat
Application
immunocytochemistry
immunoprecipitation (IP)
western blot
SAB4504315
Anti-phospho-PI3-kinase p85-α (pTyr607) antibody produced in rabbit, affinity isolated antibody,
Espèces réactives
human, mouse, rat
Application
ELISA
immunohistochemistry
western blot
SAB4504314
Anti-phospho-PI3-kinase p85-α/γ (pTyr467/199) antibody produced in rabbit, affinity isolated antibody,
Espèces réactives
human, mouse, rat
Application
ELISA
immunofluorescence
western blot
SAB5500162
Anti-PI3K P85 antibody, Rabbit monoclonal, clone SP62, recombinant, expressed in proprietary host, affinity isolated antibody,
Espèces réactives
bovine, frog, human, mouse, rat
Application
flow cytometry
immunohistochemistry
ABS1856
Anti-PI3 Kinase Antibody, p85, from rabbit, purified by affinity chromatography,
Espèces réactives
bovine, human, mouse, rat, rhesus monkey
Application
immunoprecipitation (IP)
western blot

Small Molecule - Inhibitor

Référence du produit
Description
Espèce(s)
W1628
Wortmannin, from Penicillium funiculosum, ≥98% (HPLC and TLC),
Espèce(s)
human
W3144
Wortmannin, Ready Made Solution, from Penicillium funiculosum, ≥95% (HPLC),
Espèce(s)
human
D2926
Diphenyleneiodonium chloride, ≥98%,
Espèce(s)
mouse, human
PZ0235
PF-04691502, ≥98% (HPLC),
Espèce(s)
human

esiRNA

Référence du produit
Description
Espèce(s)
EMU187151
MISSION® esiRNA, targeting mouse Pik3r1,
Espèce(s)
mouse
EHU151811
MISSION® esiRNA, targeting human PIK3R1,
Espèce(s)
human