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Merck

NEDD4L

neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase

Synonymes:
NEDD4-2, NEDD4.2, RSP5, hNEDD4-2
Espèce(s):
ID UniProtKB:
ID du gène:
  • Human(23327) Summary: This gene encodes a member of the Nedd4 family of HECT domain E3 ubiquitin ligases. HECT domain E3 ubiquitin ligases transfer ubiquitin from E2 ubiquitin-conjugating enzymes to protein substrates, thus targeting specific proteins for lysosomal degradation. The encoded protein mediates the ubiquitination of multiple target substrates and plays a critical role in epithelial sodium transport by regulating the cell surface expression of the epithelial sodium channel, ENaC. Single nucleotide polymorphisms in this gene may be associated with essential hypertension. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012]
  • Mouse(83814) neural precursor cell expressed, developmentally down-regulated gene 4-like
  • Rat(291553) neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
  • sheep(101122748) neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
  • Zebrafish(559634) neural precursor cell expressed, developmentally down-regulated 4-like
  • domestic guinea pig(100301562) neural precursor cell expressed, developmentally down-regulated gene 4-like
  • domestic cat(101088369) neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
  • Horse(100054395) neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
  • Domestic Rabbit(100353099) neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
  • cow(510003) neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
  • dog(476189) neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
  • naked mole-rat(101715398) neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
  • chicken(374119) neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase

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Antibodies

Référence du produit
Description
Espèces réactives
Application
Anti-NEDD4L antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Espèces réactives
human
Application
immunohistochemistry
Anti-NEDD4L antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
Espèces réactives
human
Application
immunofluorescence
Monoclonal Anti-NEDD4L antibody produced in mouse, clone 1D2, purified immunoglobulin, buffered aqueous solution,
Espèces réactives
human
Application
ELISA
immunoprecipitation (IP)

western blot
Anti-NEDD4L Antibody, clone 3W9J2, Rabbit Monoclonal, ,
Espèces réactives
human
Application
western blot
Anti-Phospho-NEDD4L-S448 antibody produced in rabbit, ,
Espèces réactives
human, mouse, rat
Application
western blot

esiRNA

Référence du produit
Description
Espèce(s)
MISSION® esiRNA, targeting human NEDD4L,
Espèce(s)
human
MISSION® esiRNA, targeting mouse Nedd4l,
Espèce(s)
mouse