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Merck

HDAC3

histone deacetylase 3

Synonymes:
HD3, RPD3, RPD3-2
Espèce(s):
ID UniProtKB:
ID du gène:
  • Human(8841) Summary: Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. This gene is regarded as a potential tumor suppressor gene. [provided by RefSeq, Jul 2008]
  • Mouse(15183) histone deacetylase 3
  • Rat(84578) histone deacetylase 3
  • fruit fly(44446) Histone deacetylase 3
  • Zebrafish(393965) histone deacetylase 3
  • cow(404125) histone deacetylase 3
  • chicken(395506) histone deacetylase 3
  • sheep(101107092) histone deacetylase 3
  • domestic guinea pig(100718985) histone deacetylase 3
  • dog(478040) histone deacetylase 3
  • domestic cat(101100941) histone deacetylase 3
  • naked mole-rat(101708680) histone deacetylase 3

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Antibodies

Référence du produit
Description
Espèces réactives
Application
Monoclonal Anti-HDAC3 antibody produced in mouse, clone 3E11, purified immunoglobulin, buffered aqueous solution,
Espèces réactives
human, mouse, rat
Application
ELISA
western blot
Anti-phospho-HDAC3 (pSer424) antibody produced in rabbit, affinity isolated antibody,
Espèces réactives
human, mouse, rat
Application
western blot
Anti-HDAC3 Antibody, Upstate®, from rabbit,
Espèces réactives
human, mouse, rat
Application
western blot
Anti-HDAC3 antibody produced in rabbit, affinity isolated antibody,
Espèces réactives
human, mouse, rat
Application
ELISA
immunofluorescence

immunohistochemistry

western blot
Anti-HDAC3 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Espèces réactives
human
Application
immunofluorescence
immunohistochemistry

western blot

Small Molecule - Inhibitor

Référence du produit
Description
Espèce(s)
SAHA, ≥98% (HPLC),
Espèce(s)
human
Romidepsin, ≥98% (HPLC),
Espèce(s)
human
CI−994, ≥98% (HPLC), powder,
Espèce(s)
human

Proteins

Référence du produit
Description
Espèce(s)
HDAC3 human, recombinant, expressed in insect cells, ≥70% (SDS-PAGE),
Espèce(s)
human

esiRNA

Référence du produit
Description
Espèce(s)
MISSION® esiRNA, targeting human HDAC3,
Espèce(s)
human
MISSION® esiRNA, targeting mouse Hdac3,
Espèce(s)
mouse