DCC
deleted in colorectal carcinoma
Synonymes:
CRC18, CRCR1, IGDCC1, MRMV1
Espèce(s):
Human DCC (1630), Mouse Dcc (13176), Rat Dcc (25311), Zebrafish dcc (569360), dog DCC (483976), domestic cat DCC (101098832), Horse DCC (100054013), cow DCC (537176), sheep DCC (101118654), domestic guinea pig Dcc (100712666)
ID UniProtKB:
ID du gène:
- Human(1630) Summary: This gene encodes a netrin 1 receptor. The transmembrane protein is a member of the immunoglobulin superfamily of cell adhesion molecules, and mediates axon guidance of neuronal growth cones towards sources of netrin 1 ligand. The cytoplasmic tail interacts with the tyrosine kinases Src and focal adhesion kinase (FAK, also known as PTK2) to mediate axon attraction. The protein partially localizes to lipid rafts, and induces apoptosis in the absence of ligand. The protein functions as a tumor suppressor, and is frequently mutated or downregulated in colorectal cancer and esophageal carcinoma. [provided by RefSeq, Oct 2009]
- Mouse(13176) deleted in colorectal carcinoma
- Rat(25311) deleted in colorectal carcinoma
- Zebrafish(569360) deleted in colorectal carcinoma
- dog(483976) deleted in colorectal carcinoma
- domestic cat(101098832) deleted in colorectal carcinoma
- Horse(100054013) deleted in colorectal carcinoma
- cow(537176) deleted in colorectal carcinoma
- sheep(101118654) deleted in colorectal carcinoma
- domestic guinea pig(100712666) deleted in colorectal carcinoma
- naked mole-rat(101705571) deleted in colorectal carcinoma
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Antibodies
Référence du produit
Description
Espèces réactives
Application
Anti-DCC antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Espèces réactives
human
Application
immunohistochemistry
Anti-DCC antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
Espèces réactives
human
Application
immunofluorescence
Anti-DCC antibody produced in rabbit, affinity isolated antibody,
Espèces réactives
human, mouse, rat
Application
ELISA
immunofluorescence
immunofluorescence
Anti-phospho DCC (Tyr1418), serum, from rabbit,
Espèces réactives
rat
Application
dot blot
immunofluorescence
western blot
immunofluorescence
western blot
Anti-DCC antibody produced in rabbit, affinity isolated antibody,
Espèces réactives
dog, guinea pig, horse, human, mouse, rabbit, rat
Application
western blot
esiRNA
Référence du produit
Description
Espèce(s)