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Merck

CYP19A1

cytochrome P450, family 19, subfamily A, polypeptide 1

Synonymes:
ARO, ARO1, CPV1, CYAR, CYP19, CYPXIX, P-450AROM
Espèce(s):
Human CYP19A1 (1588), Mouse Cyp19a1 (13075), Rat Cyp19a1 (25147), Goat CYP19A1 (100861413), Horse CYP19A1 (100009712), dog CYP19A1 (494003), chicken CYP19A1 (414854), Domestic Rabbit CYP19A1 (100328545), cow CYP19A1 (281740)
ID UniProtKB:
P11511, Q16731, Q3B764, Q58FA0
ID du gène:
  • Human(1588) Summary: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and catalyzes the last steps of estrogen biosynthesis, three successive hydroxylations of the A ring of androgens. Mutations in this gene can result in either increased or decreased aromatase activity; the associated phenotypes suggest that estrogen functions both as a sex steroid hormone and in growth or differentiation. The gene expresses two transcript variants. [provided by RefSeq, Jul 2008]
  • Mouse(13075) cytochrome P450, family 19, subfamily a, polypeptide 1
  • Rat(25147) cytochrome P450, family 19, subfamily a, polypeptide 1
  • Goat(100861413) cytochrome P450, family 19, subfamily A, polypeptide 1
  • Horse(100009712) cytochrome P450, family 19, subfamily A, polypeptide 1
  • dog(494003) cytochrome P450, family 17, subfamily A, polypeptide 1
  • chicken(414854) cytochrome P450, family 19, subfamily A, polypeptide 1
  • Domestic Rabbit(100328545) cytochrome P450, family 19, subfamily A, polypeptide 1
  • cow(281740) cytochrome P450, family 19, subfamily A, polypeptide 1

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Antibodies

Référence du produit
Description
Espèces réactives
Application
SAB4500606
Anti-Cytochrome P450 19A1 antibody produced in rabbit, affinity isolated antibody,
Espèces réactives
human, mouse, rat
Application
ELISA
immunofluorescence
immunohistochemistry
western blot
HPA051194
Anti-CYP19A1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Espèces réactives
human
Application
immunofluorescence
immunohistochemistry
ABN30
Anti-Aromatase Antibody, from rabbit, purified by affinity chromatography,
Espèces réactives
bovine, canine, chimpanzee, human, pig, porcine, rhesus macaque
Application
western blot
ZRB2945
Anti-Aromatase Antibody, clone 1D23 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Espèces réactives
human, monkey
Application
affinity binding assay
immunohistochemistry
western blot
SAB5702040
Anti-Aromatase (CYP19A1) Antibody, clone 5C5N7, Rabbit Monoclonal, ,
Espèces réactives
human
Application
immunofluorescence
immunohistochemistry
western blot

Cell Lines

Référence du produit
Description
Espèce(s)
MTOXCE19A1
CypExpress™ Aromatase, ,
Espèce(s)
human

Small Molecule - Inhibitor

Référence du produit
Description
Espèce(s)
L6545
Letrozole, ≥98% (HPLC),
Espèce(s)
human
PHR1540
Letrozole, Pharmaceutical Secondary Standard; Certified Reference Material,
Espèce(s)
human
PZ0006
Exemestane, ≥98% (HPLC),
Espèce(s)
human
F2552
Formestane, solid,
Espèce(s)
human
1356971
Letrozole, United States Pharmacopeia (USP) Reference Standard,
Espèce(s)
human

Small Molecule - Ligand

Référence du produit
Description
Espèce(s)
A9657
DL-Aminoglutethimide, ,
Espèce(s)
human, rat

esiRNA

Référence du produit
Description
Espèce(s)
EMU044241
MISSION® esiRNA, targeting mouse Cyp19a1,
Espèce(s)
mouse
EHU036781
MISSION® esiRNA, targeting human CYP19A1,
Espèce(s)
human