CASP1
caspase 1, apoptosis-related cysteine peptidase
Synonymes:
ICE, IL1BC, P45
Espèce(s):
Human CASP1 (834), Mouse Casp1 (12362), Rat Casp1 (25166), chicken CASP1 (395764), cow CASP1 (514214), Horse CASP1 (100033888), domestic cat CASP1 (493961), naked mole-rat Casp1 (101725179)
ID UniProtKB:
ID du gène:
- Human(834) Summary: This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. This gene was identified by its ability to proteolytically cleave and activate the inactive precursor of interleukin-1, a cytokine involved in the processes such as inflammation, septic shock, and wound healing. This gene has been shown to induce cell apoptosis and may function in various developmental stages. Studies of a similar gene in mouse suggest a role in the pathogenesis of Huntington disease. Alternative splicing results in transcript variants encoding distinct isoforms. [provided by RefSeq, Mar 2012]
- Mouse(12362) caspase 1
- Rat(25166) caspase 1
- chicken(395764) caspase 1, apoptosis-related cysteine peptidase
- cow(514214) caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)
- Horse(100033888) caspase 1, apoptosis-related cysteine peptidase
- domestic cat(493961) caspase 1, apoptosis-related cysteine peptidase
- naked mole-rat(101725179) caspase 1, apoptosis-related cysteine peptidase
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Antibodies
Référence du produit
Description
Espèces réactives
Application
Anticorps anti-caspase 1, from rabbit, purified by affinity chromatography,
Espèces réactives
human
Application
immunohistochemistry
western blot
western blot
Anti-Caspase 1 antibody produced in rabbit, ,
Espèces réactives
human, mouse, rat
Application
immunofluorescence
immunohistochemistry
immunoprecipitation (IP)
western blot
immunohistochemistry
immunoprecipitation (IP)
western blot
Anti-CASP-1 (Cleaved-Asp210) antibody produced in rabbit, affinity isolated antibody,
Espèces réactives
human
Application
ELISA
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-Caspase-1 (ab1) antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution,
Espèces réactives
human
Application
ELISA
immunofluorescence
immunohistochemistry
western blot
immunofluorescence
immunohistochemistry
western blot
Anti-Caspase-1 (ab2) antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution,
Espèces réactives
human
Application
ELISA
immunofluorescence
immunohistochemistry
western blot
immunofluorescence
immunohistochemistry
western blot
Small Molecule - Inhibitor
esiRNA
Référence du produit
Description
Espèce(s)